氮芥、丙卡巴肼和泼尼松用于治疗犬难治性淋巴瘤。

Mechlorethamine, procarbazine and prednisone for the treatment of resistant lymphoma in dogs.

作者信息

Northrup N C, Gieger T L, Kosarek C E, Saba C F, LeRoy B E, Wall T M, Hume K R, Childress M O, Keys D A

机构信息

Comparative Oncology Program, Department of Small Animal Medicine and Surgery, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA.

出版信息

Vet Comp Oncol. 2009 Mar;7(1):38-44. doi: 10.1111/j.1476-5829.2008.00170.x.

DOI:10.1111/j.1476-5829.2008.00170.x

PMID:19222829

Abstract

Forty-one dogs with resistant lymphoma were treated with a modified MOPP (mechlorethamine, vincristine, procarbazine and prednisone) protocol (MPP [mechlorethamine, procarbazine and prednisone] administered on a 21-day cycle, shortened from the 28-day MOPP cycle). The overall response rate to MPP was 34% for a median of 56 days (95% confidence interval 30-238). Seventeen percent of dogs had a complete response for a median duration of 238 days, 17% had a partial response for a median of 56 days and 32% had stable disease for a median of 24 days. Histological grade or cell morphology on cytology was associated with response. Minimal toxicity was observed with the MPP protocol, suggesting that further dose intensification or addition of another chemotherapeutic agent would be possible.

摘要

41只患有难治性淋巴瘤的犬接受了改良的MOPP（氮芥、长春新碱、丙卡巴肼和泼尼松）方案（MPP[氮芥、丙卡巴肼和泼尼松]以21天为周期给药，从28天的MOPP周期缩短而来）治疗。MPP的总体缓解率为34%，中位缓解持续时间为56天（95%置信区间30 - 238天）。17%的犬完全缓解，中位持续时间为238天；17%部分缓解，中位持续时间为56天；32%病情稳定，中位持续时间为24天。组织学分级或细胞学上的细胞形态与缓解情况相关。MPP方案观察到的毒性最小，这表明进一步增加剂量强度或添加另一种化疗药物是可行的。