Pang P K, Lewanczuk R Z
Department of Physiology, University of Alberta, Edmonton, Canada.
Am J Hypertens. 1989 Dec;2(12 Pt 1):898-902. doi: 10.1093/ajh/2.12.898.
The parathyroid gland has been causally associated with some forms of hypertension, yet parathyroid hormone (PTH) has been shown to possess hypotensive properties. Recently, we described the presence of a circulating hypertensive factor in spontaneously hypertensive rat (SHR) plasma, the expression of which is associated with a novel cell type in the parathyroid gland. In order to determine whether this hypertensive factor might be produced by the parathyroid gland, the effects of parathyroidectomy and parathyroid transplantation on mean arterial pressure (MAP) and hypertensive factor activity were studied. Parathyroidectomy, but not sham operation, decreased MAP in SHR and resulted in the disappearance of the hypertensive factor from the plasma. Transplantation of SHR parathyroid glands into Sprague-Dawley (SD) rats resulted in an increase in MAP and the appearance of the factor in the plasma, whereas transplantation of SD parathyroid glands into SHR had exactly the opposite effect. SD to SD transplantation had no effect on MAP or hypertensive factor activity. Infusions of PTH gave opposite effects to hypertensive factor infusions. These results suggest that the hypertensive factor is parathyroid gland-dependent but is not PTH. On this basis, we have proposed that the factor be referred to as "Parathyroid Hypertensive Factor," or "PHF."
甲状旁腺已被证实与某些类型的高血压存在因果关系，然而甲状旁腺激素（PTH）却具有降压特性。最近，我们描述了自发性高血压大鼠（SHR）血浆中存在一种循环性高血压因子，其表达与甲状旁腺中的一种新型细胞类型有关。为了确定这种高血压因子是否由甲状旁腺产生，我们研究了甲状旁腺切除术和甲状旁腺移植对平均动脉压（MAP）和高血压因子活性的影响。甲状旁腺切除术而非假手术降低了SHR的MAP，并导致血浆中高血压因子消失。将SHR的甲状旁腺移植到Sprague-Dawley（SD）大鼠体内导致MAP升高且血浆中出现该因子，而将SD的甲状旁腺移植到SHR体内则产生相反的效果。SD大鼠之间的移植对MAP或高血压因子活性没有影响。输注PTH产生的效果与输注高血压因子相反。这些结果表明，高血压因子依赖于甲状旁腺，但不是PTH。在此基础上，我们提议将该因子称为“甲状旁腺高血压因子”，或“PHF”。
