Nahm Dong-Ho, Kim Myoung-Eun, Cho Su-Mi
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Dermatology. 2015;231(2):145-51. doi: 10.1159/000431173. Epub 2015 Jun 20.
BACKGROUND/OBJECTIVE: The management of patients with atopic dermatitis (AD) is often difficult for both patients and physicians. We hypothesized that repeated intramuscular injections of autologous immunoglobulin can induce clinical improvement in patients with AD by correcting immune dysfunction.
Seventeen adult patients with severe AD were treated by intramuscular injection of 50 mg autologous immunoglobulin (mainly IgG with a purity ≥97%) twice a week for 4 weeks. The standardized clinical severity scoring system for AD (SCORAD) value and serum IgE concentration were measured at baseline and at 4, 8, and 12 weeks.
SCORAD values and serum IgE concentrations significantly decreased at 4, 8, and 12 weeks compared to baseline (p < 0.05). No significant side effects were observed.
Repeated intramuscular injections of autologous immunoglobulin significantly decreased the clinical severity and serum IgE concentration in patients with severe AD. Further studies are required to evaluate the clinical significance of these findings.
背景/目的：特应性皮炎（AD）患者的管理对患者和医生来说往往都很困难。我们推测，反复肌肉注射自体免疫球蛋白可通过纠正免疫功能障碍诱导AD患者临床症状改善。
17例重度AD成年患者接受每周两次、每次50mg自体免疫球蛋白（主要为纯度≥97%的IgG）肌肉注射，共4周。在基线以及第4、8和12周时测量AD标准化临床严重程度评分系统（SCORAD）值和血清IgE浓度。
与基线相比，第4、8和12周时SCORAD值和血清IgE浓度显著降低（p<0.05）。未观察到明显副作用。
反复肌肉注射自体免疫球蛋白可显著降低重度AD患者的临床严重程度和血清IgE浓度。需要进一步研究来评估这些发现的临床意义。
