Iushmanov V E, Mitskevich V A
Biofizika. 1989 Sep-Oct;34(5):854-7.
Distribution and dynamical characteristics of water molecules in normal and degeneratively changed rabbit intervertebral discs (ID) are estimated basing on the biexponential relaxation analysis of MR-images. Degenerative-dystrophic changes in a rabbit spine were modelled via a spine segmental blood supply injury and, in some cases, removal of ID nuclei. Extreme distributions of relaxation parameters in the ID plane characteristic of intact IDs are shown to be disturbed in cases of ID degenerative changes. These results allow to link ID fibrosis to a water balance disorder and to give a method for estimating the spine destruction degree for clinical MR-imaging.
基于磁共振图像的双指数弛豫分析，估计正常和退变兔椎间盘（ID）中水分子的分布和动力学特征。通过脊柱节段性血供损伤，在某些情况下通过去除椎间盘髓核来模拟兔脊柱的退行性营养不良变化。结果表明，在椎间盘退变时，完整椎间盘特征性的弛豫参数在椎间盘平面的极端分布受到干扰。这些结果有助于将椎间盘纤维化与水平衡紊乱联系起来，并为临床磁共振成像评估脊柱破坏程度提供一种方法。
