Mayra Pastore R, Rosalina Villalón L, López Gladys, Iruretagoyena Jesús, Magness Ronald
Programa de Endocrinología y Fisiología Reproductiva, Universidad de Wisconsin-Madison, Wisconsin, USA ; Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecología y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA.
Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecología y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento Perinatal, Universidad de Wisconsin-Madison, Wisconsin, USA.
Rev Chil Obstet Ginecol. 2014 Jun;79(3):218-228. doi: 10.4067/S0717-75262014000300011.
Pregnancy is marked by changes and cardiovascular adaptations that are important for the maintenance and growth of the placenta and fetus. During this period, the uterine vascular adaptations manifest changes that can be classified as short or long term and they related to adaptations for vasodilation, angiogenic or remodeling. Estrogen and the classical estrogen receptors (ERs), ER-α and ER-β, have been shown to be partially responsible for facilitating this dramatic increase in uterine blood flow needed during pregnancy. This literature review discusses the basis for structural diversity and functional selectivity of ERs by estrogen, the role of ERs on the genomic and non-genomic effects in endothelial cells of uterine arteries (UAEC). These themes integrate scientific knowledge about the molecular regulation of UAEC to maintain the physiological increase in uteroplacental perfusion observed during normal pregnancy.
怀孕的特征是发生各种变化以及心血管系统的适应性改变，这些对于胎盘和胎儿的维持与生长至关重要。在此期间，子宫血管适应性表现出的变化可分为短期或长期，且与血管舒张、血管生成或重塑的适应性有关。雌激素以及经典的雌激素受体（ERs），即ER-α和ER-β，已被证明在促进孕期所需的子宫血流量显著增加方面发挥了部分作用。这篇文献综述讨论了雌激素导致ERs结构多样性和功能选择性的基础，以及ERs在子宫动脉内皮细胞（UAEC）的基因组和非基因组效应中的作用。这些主题整合了关于UAEC分子调控的科学知识，以维持正常孕期观察到的子宫胎盘灌注的生理性增加。
