Gould Jacqueline F, Anderson Amanda J, Yelland Lisa N, Smithers Lisa G, Skeaff C Murray, Gibson Robert A, Makrides Maria
Women's and Children's Health Research Institute, North Adelaide, SA, Australia.
School of Population Health, University of Adelaide, Adelaide, SA, Australia.
Aust N Z J Obstet Gynaecol. 2015 Oct;55(5):446-52. doi: 10.1111/ajo.12344. Epub 2015 Jun 30.
Observational studies have implicated low serum vitamin D (25-hydroxyvitamin D (25(OH)D)) levels in the development of mood disorders. Postpartum depression (PPD) is an important public health issue, although little is known about its association with serum 25(OH)D.
To determine the association between 25(OH)D at delivery and the subsequent risk of PPD at six weeks and six months postpartum in a large cohort of Australian women.
Cord blood samples from 1040 women participating in the docosahexaenoic acid (DHA) to Optimise Maternal Infant Outcome randomised controlled trial were analysed for 25(OH)D by mass spectroscopy. Maternal PPD was assessed using the Edinburgh Postnatal Depression Scale at six weeks and six months postpartum. The association between standardised 25(OH)D and PPD was assessed, taking into account DHA treatment, social and demographic variables.
There was no association between cord blood 25(OH)D concentration at delivery and PPD at either six weeks or six months postpartum. Cord blood 25(OH)D 25-50 and >50 nmol/L at delivery was associated with decreased risk of PPD at six weeks postpartum compared with 25(OH)D <25 nmol/L in the control group, but not the DHA group. There was no association between cord blood 25(OH)D <25 nmol/L at delivery and PPD at six months postpartum.
This largest study to date of 25(OH)D levels at delivery and PPD did not reveal a consistent link with PPD.
观察性研究表明血清维生素D（25-羟基维生素D（25(OH)D））水平低与情绪障碍的发生有关。产后抑郁症（PPD）是一个重要的公共卫生问题，尽管对其与血清25(OH)D的关联知之甚少。
在一大群澳大利亚女性中，确定分娩时的25(OH)D与产后六周和六个月时PPD后续风险之间的关联。
对参与二十二碳六烯酸（DHA）优化母婴结局随机对照试验的1040名女性的脐带血样本进行质谱分析，以检测25(OH)D。在产后六周和六个月时，使用爱丁堡产后抑郁量表评估产妇的PPD。在考虑DHA治疗、社会和人口统计学变量的情况下，评估标准化25(OH)D与PPD之间的关联。
分娩时脐带血25(OH)D浓度与产后六周或六个月时的PPD均无关联。与对照组中25(OH)D<25 nmol/L相比，分娩时脐带血25(OH)D为25 - 50 nmol/L和>50 nmol/L与产后六周时PPD风险降低相关，但DHA组无此关联。分娩时脐带血25(OH)D<25 nmol/L与产后六个月时的PPD无关联。
这项迄今为止关于分娩时25(OH)D水平与PPD的最大规模研究未发现与PPD存在一致的联系。
