Yuan Yamin, Qu Liyuan, Sun Qiufeng, He Peina, Zhou Xiaohuan
Department of Clinical Nursing, School of Nursing, Pingdingshan University, Medical School, Pingdingshan, Henan Province, China.
Outpatient Department, Henan Urban Construction University School Hospital, Pingdingshan, Henan Province, China.
Alpha Psychiatry. 2024 Nov 1;25(6):669-675. doi: 10.5152/alphapsychiatry.2024.241553. eCollection 2024 Nov.
To conduct a meta-analysis on the connection between vitamin D deficiency and perinatal depression.
A comprehensive literature search was conducted across several databases, including PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, and VIP database. Two reviewers independently assessed the risk of bias in articles using the Cochrane collaboration's tool, with analysis performed via RevMan software.
After reviewing major databases, 13 studies were included. Three studies assessed prenatal depression and vitamin D levels, showing significantly lower levels in the depression group compared to controls (Standardized Mean Difference [SMD] = -0.41, 95% Confidence Interval [CI] -0.57 to -0.25) with minimal heterogeneity, thus a fixed effects model was used. Another three studies explored postpartum depression and vitamin D, revealing considerable heterogeneity ( = 96%, < .01), leading to the use of a random effects model; these indicated much lower vitamin D levels in the depression group (SMD = -1.62, 95% CI -2.62 to -0.62). Seven studies examined the link between postpartum depression and vitamin D deficiency, again showing significant heterogeneity ( = 92%, < .01) and lower vitamin D levels in depressed women (SMD [Standardized Mean Difference] = 2.28, 95% CI 1.60-3.25), with no significant publication bias detected.
Reduced vitamin D levels are significantly associated with the incidence of perinatal depression. Pregnant women with reduced vitamin D levels have a relatively higher risk of depression. This signifies that vitamin D levels may figure prominently in maintaining maternal mental health.
对维生素D缺乏与围产期抑郁症之间的关联进行荟萃分析。
在多个数据库中进行全面的文献检索，包括PubMed、Web of Science、Embase、Cochrane图书馆、中国知网和维普数据库。两名评审员使用Cochrane协作工具独立评估文章的偏倚风险，并通过RevMan软件进行分析。
在检索主要数据库后，纳入了13项研究。三项研究评估了产前抑郁症与维生素D水平，结果显示抑郁症组的维生素D水平显著低于对照组（标准化均数差[SMD]=-0.41，95%置信区间[CI]-0.57至-0.25），异质性最小，因此采用固定效应模型。另外三项研究探讨了产后抑郁症与维生素D的关系，显示出相当大的异质性（I²=96%，P<0.01），因此采用随机效应模型；这些研究表明抑郁症组的维生素D水平低得多（SMD=-1.62，95%CI-2.62至-0.62）。七项研究考察了产后抑郁症与维生素D缺乏之间的联系，再次显示出显著的异质性（I²=92%，P<0.01），且抑郁症女性的维生素D水平较低（标准化均数差[SMD]=2.28，95%CI 1.60-3.25），未检测到显著的发表偏倚。
维生素D水平降低与围产期抑郁症的发生率显著相关。维生素D水平降低的孕妇患抑郁症的风险相对较高。这表明维生素D水平可能在维持孕产妇心理健康方面起着重要作用。
