过氧化物酶体增殖物激活受体γ及其配体：消化系统中的潜在抗肿瘤药物。

PPARγ and Its Ligands: Potential Antitumor Agents in the Digestive System.

作者信息

Shu Linjing, Huang Renhuan, Wu Songtao, Chen Zhaozhao, Sun Ke, Jiang Yan, Cai Xiaoxiao

机构信息

State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No. 14., 3rd Sec., Ren Min Nan Road, Chengdu 610041, P. R. China.

出版信息

Curr Stem Cell Res Ther. 2016;11(3):274-81. doi: 10.2174/1574888x10666150630111618.

DOI:10.2174/1574888x10666150630111618

PMID:26122910

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligand-activated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can suppress the growth of oral, esophageal, gastric, colorectal, liver, biliary, and pancreatic tumor cells, suggesting that PPARγ ligand is a potential anticancer agent in PPARγ-expressing tumors. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the digestive system.

摘要

过氧化物酶体增殖物激活受体γ（PPARγ）是转录因子配体激活核激素受体超家族中的一个多功能成员，在多种不同细胞系中表达，尤其是在消化系统。被其配体激活后，PPARγ可抑制口腔、食管、胃、结肠、肝、胆和胰腺肿瘤细胞的生长，这表明PPARγ配体是表达PPARγ的肿瘤中的一种潜在抗癌剂。本文综述了在理解PPARγ配体对消化系统肿瘤治疗作用方面的关键进展。