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On the mechanism of ligand binding to myoglobin. The role of structural fluctuations.

作者信息

Doster W

机构信息

Physik Department, Technische Universität München, Garching, Federal Republic of Germany.

出版信息

Eur Biophys J. 1989;17(4):217-20. doi: 10.1007/BF00284728.

DOI:10.1007/BF00284728
PMID:2612440
Abstract

The association reaction of CO and O2 with heme is expected to reflect the differences in the electronic structures of the two ligands. CO binding should be controlled by a high spin/low spin transition while oxygen binding is spin-allowed. Dioxygen should thus bind substantially faster than CO. The experimental association rates of the two ligands are, however, almost identical. We propose that the reaction is triggered in both cases by a fast structural intermediate which allows the CO molecule to bind adiabatically. A suitable structural transition has been identified recently by inelastic neutron scattering.

摘要

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引用本文的文献

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本文引用的文献

1
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J Mol Biol. 1980 Oct 5;142(4):531-54. doi: 10.1016/0022-2836(80)90262-4.
2
Solvent viscosity and protein dynamics.溶剂粘度与蛋白质动力学。
Biochemistry. 1980 Nov 11;19(23):5147-57. doi: 10.1021/bi00564a001.
3
Quaternary structures and low frequency molecular vibrations of haems of deoxy and oxyhaemoglobin studied by resonance raman scattering.通过共振拉曼散射研究脱氧血红蛋白和氧合血红蛋白血红素的四级结构及低频分子振动。
J Mol Biol. 1980 Jan 25;136(3):271-89. doi: 10.1016/0022-2836(80)90374-5.
4
Protein dynamics. Mössbauer spectroscopy on deoxymyoglobin crystals.蛋白质动力学。脱氧肌红蛋白晶体的穆斯堡尔光谱学。
J Mol Biol. 1982 Oct 15;161(1):177-94. doi: 10.1016/0022-2836(82)90285-6.
5
Control and pH dependence of ligand binding to heme proteins.配体与血红素蛋白结合的控制及pH依赖性
Biochemistry. 1982 Sep 28;21(20):4831-9. doi: 10.1021/bi00263a001.
6
Relaxation process on a picosecond time scale in hemoglobin and poly(L-alanine) observed by millimeter-wave spectroscopy.通过毫米波光谱法观察到的血红蛋白和聚（L-丙氨酸）中皮秒时间尺度上的弛豫过程。
Biopolymers. 1983 Jul;22(7):1715-29. doi: 10.1002/bip.360220708.
7
Dynamics of heme iron in crystals of metmyoglobin and deoxymyoglobin.高铁肌红蛋白和脱氧肌红蛋白晶体中血红素铁的动力学
Proc Natl Acad Sci U S A. 1983 Feb;80(3):736-40. doi: 10.1073/pnas.80.3.736.
8
Femtosecond photolysis of CO-ligated protoheme and hemoproteins: appearance of deoxy species with a 350-fsec time constant.一氧化碳连接的原血红素和血红蛋白的飞秒光解：具有350飞秒时间常数的脱氧物种的出现。
Proc Natl Acad Sci U S A. 1983 Jan;80(1):173-7. doi: 10.1073/pnas.80.1.173.
9
Hemoglobin-carbon monoxide binding rate. Low temperature magneto-optical detection of spin-tunneling.血红蛋白-一氧化碳结合率。自旋隧道效应的低温磁光检测。
Biophys J. 1981 Aug;35(2):471-84. doi: 10.1016/S0006-3495(81)84803-5.
10
Do vibrational spectroscopies uniquely describe protein dynamics? The case for myoglobin.振动光谱能独特地描述蛋白质动力学吗？以肌红蛋白为例。
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