Landry T D, Johnson K A, Phillips J E, Weiss S K
Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674.
Fundam Appl Toxicol. 1989 Oct;13(3):516-22. doi: 10.1016/0272-0590(89)90288-1.
Groups of seven B6C3F1 mice per sex were exposed for 23 hr/day to 0, 250, 1250, or 5000 ppm ethyl chloride (EtCl) for 11 consecutive days to evaluate the potential toxicity of EtCl under near-continuous exposure conditions. On the day following the last exposure, a neurobehavioral observation battery was performed, samples were obtained for clinical chemistry and hematology, and necropsies were conducted. Histopathologic examination was subsequently performed. The only observed effects were increased relative liver weights and a slight increase in hepatocellular vacuolation (glycogen or fat) in 5000 ppm-exposed mice. Exposures to EtCl were well tolerated despite the unusually long exposure periods.
每组七只不同性别的B6C3F1小鼠，每天23小时暴露于0、250、1250或5000 ppm的氯乙烷（EtCl）中，连续暴露11天，以评估在近乎连续暴露条件下EtCl的潜在毒性。在最后一次暴露后的当天，进行神经行为观察，采集样本进行临床化学和血液学检测，并进行尸检。随后进行组织病理学检查。唯一观察到的影响是，暴露于5000 ppm EtCl的小鼠肝脏相对重量增加，肝细胞空泡化（糖原或脂肪）略有增加。尽管暴露时间异常长，但小鼠对EtCl的暴露耐受性良好。
