L型氨基酸转运体-1与CD98在骨与软组织肿瘤中的表达
L-type amino acid transporter-1 and CD98 expression in bone and soft tissue tumors.
作者信息
Koshi Hiromi, Sano Takaaki, Handa Tadashi, Yanagawa Takashi, Saitou Kenichi, Nagamori Shushi, Kanai Yoshikatsu, Takagishi Kenji, Oyama Tetsunari
机构信息
Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
出版信息
Pathol Int. 2015 Sep;65(9):460-7. doi: 10.1111/pin.12323. Epub 2015 Jul 1.
L-type amino acid transporter-1 (LAT1) is expressed in many cancers. We examined LAT1 and CD98 expression immunohistochemically in surgically resected specimens of various bone and soft tissue tumors. Out of 226 cases, 79 (35%) were LAT1(+) and 95 (42%) were CD98(+) . In bone tumors, LAT1 was highly expressed in osteoblastoma (89%), chondrosarcoma (50%), and osteosarcoma (60%); in soft tissue tumors, LAT1 was highly expressed in rhabdomyosarcoma (80%), synovial sarcoma (63%), Ewing's sarcoma (60%), epithelioid sarcoma (100%) and angiosarcoma (100%). In malignant soft tissue tumors, LAT1 expression was associated with higher histological grade. High CD98 expression was seen in many bone tumors of intermediate and high malignancy. Among soft tissue tumors, CD98 was expressed in tendon sheath giant cell tumor and malignant peripheral nerve sheath tumor (57%), Ewing's sarcoma (50%) and undifferentiated sarcoma (64%). Some of the malignant soft tissue tumors expressed both LAT1 and CD98. This study showed that LAT1 and CD98 was expressed in many malignant and intermediate bone tumors, and some malignant soft tissue tumors.
L型氨基酸转运体-1（LAT1）在多种癌症中均有表达。我们采用免疫组织化学方法检测了各种骨与软组织肿瘤手术切除标本中LAT1和CD98的表达情况。在226例病例中，79例（35%）LAT1呈阳性，95例（42%）CD98呈阳性。在骨肿瘤中，成骨细胞瘤（89%）、软骨肉瘤（50%）和骨肉瘤（60%）中LAT1高表达；在软组织肿瘤中，横纹肌肉瘤（80%）、滑膜肉瘤（63%）、尤因肉瘤（60%）、上皮样肉瘤（100%）和血管肉瘤（100%）中LAT1高表达。在恶性软组织肿瘤中，LAT1表达与较高的组织学分级相关。在许多中高恶性度的骨肿瘤中可见CD98高表达。在软组织肿瘤中，腱鞘巨细胞瘤和恶性外周神经鞘瘤（57%）、尤因肉瘤（50%）和未分化肉瘤（64%）中表达CD98。一些恶性软组织肿瘤同时表达LAT1和CD98。本研究表明，LAT1和CD98在许多恶性和中间性骨肿瘤以及一些恶性软组织肿瘤中均有表达。
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