Zhang Jingshun, Xu Ying, Li Dandan, Fu Lulu, Zhang Xueying, Bao Yigang, Zheng Lianwen
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.
Front Chem. 2020 Oct 20;8:564809. doi: 10.3389/fchem.2020.564809. eCollection 2020.
LAT1 is a member of the system L transporter family. The main role of the LAT1 is to transport specific amino acids through cell membranes to provide nutrients to cells and participate in several metabolic pathways. It also contributes to the transport of hormones and some drugs, which are essential for the development and treatment of some diseases. In recent years, many studies have shown that LAT1 is related to cancer, obesity, diabetes, and other diseases. However, the specific mechanism underlying the influence of LAT1 on such conditions remains unclear. Through the increasing number of studies on LAT1, we have obtained a preliminary understanding on the function of LAT1 in diseases. These studies also provide a theoretical basis for finding treatments for LAT1-related diseases, such as cancer. This review summarizes the function and mechanism of LAT1 in different diseases and the treatment of LAT1-related diseases. It also provides support for the development of novel and reliable disease treatments.
LAT1是L系统转运蛋白家族的成员。LAT1的主要作用是通过细胞膜转运特定氨基酸，为细胞提供营养并参与多种代谢途径。它还有助于激素和一些药物的转运，而这些对于某些疾病的发展和治疗至关重要。近年来，许多研究表明LAT1与癌症、肥胖症、糖尿病及其他疾病有关。然而，LAT1影响这些病症的具体机制仍不清楚。通过对LAT1越来越多的研究，我们对LAT1在疾病中的功能有了初步了解。这些研究也为寻找LAT1相关疾病（如癌症）的治疗方法提供了理论基础。本综述总结了LAT1在不同疾病中的功能和机制以及LAT1相关疾病的治疗方法。它还为开发新颖可靠的疾病治疗方法提供了支持。
