Ramhamadany E, Dasgupta P, Brigden G, Lahiri A, Raftery E B, Baird I M
Department of Medicine, West Middlesex University Hospital, Isleworth, UK.
Int J Obes. 1989;13 Suppl 2:95-9.
The effect of 330 kcal/day diet on cardiac function, blood pressure and cardiac chambers was studied in 34 obese subjects, using radionuclide ventriculography, intra-arterial ambulatory blood pressure recording and echocardiography. The group included 15 hypertensives and nine with coronary artery disease. After 4 weeks dieting, mean body weight fell from 105.6 +/- 22 kg to 96.1 +/- 19 kg (P less than 0.001), mean blood pressure fell from 157 +/- 23 to 144 +/- 21 mmHg systolic and 90 +/- 15 to 85 +/- 13 mmHg diastolic (P less than 0.001). The resting left ventricular ejection fraction after dieting fell significantly only in the hypertensive group (P less than 0.0005). Left ventricular ejection fraction response to exercise was impaired in all subjects. After weight loss this returned to normal except in the coronary artery disease group. There was a significant reduction in left ventricular internal dimensions, left ventricular fraction shortening and left ventricular mass after weight loss.
在34名肥胖受试者中，采用放射性核素心室造影、动脉动态血压记录和超声心动图，研究了每日330千卡饮食对心脏功能、血压和心腔的影响。该组包括15名高血压患者和9名冠状动脉疾病患者。节食4周后，平均体重从105.6±22千克降至96.1±19千克（P<0.001），平均血压收缩压从157±23降至144±21毫米汞柱，舒张压从90±15降至85±13毫米汞柱（P<0.001）。节食后静息左心室射血分数仅在高血压组显著下降（P<0.0005）。所有受试者运动时左心室射血分数反应均受损。体重减轻后，除冠状动脉疾病组外，其余均恢复正常。体重减轻后，左心室内径、左心室缩短分数和左心室质量显著降低。
