Andrews David M, Degorce Sébastien L, Drake David J, Gustafsson Magnus, Higgins Kevin M, Winter Jon J
Oncology iMed Chemistry, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TF, UK.
Oncology iMed Chemistry, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TF, UK.
Drug Discov Today. 2015 Oct;20(10):1250-5. doi: 10.1016/j.drudis.2015.06.011. Epub 2015 Jun 29.
A growing number of early discovery collaborative agreements are being put in place between large pharma companies and partners in which the rights for assets can reside with a partner, exclusively or jointly. Our corporate screening collection, like many others, was built on the premise that compounds generated in-house and not the subject of paper or patent disclosure were proprietary to the company. Collaborative screening arrangements and medicinal chemistry now make the origin, ownership rights and usage of compounds difficult to determine and manage. The Compound Passport Service is a dynamic database, managed and accessed through a set of reusable services that borrows from social media concepts to allow sample owners to take control of their samples in a much more active way.
大型制药公司与合作伙伴之间正在建立越来越多的早期发现合作协议,在这些协议中,资产权利可以完全或共同归属于合作伙伴。我们公司的筛选库和许多其他筛选库一样,是基于这样一个前提建立的:公司内部生成且未在论文或专利中披露的化合物归公司所有。合作筛选安排和药物化学现在使得化合物的来源、所有权和使用难以确定和管理。化合物护照服务是一个动态数据库,通过一组可重复使用的服务进行管理和访问,这些服务借鉴了社交媒体的概念,使样品所有者能够以更加主动的方式掌控自己的样品。