液相色谱-串联质谱法测定饮用水中的四种双酚类化合物
[Determination of four bisphenolic compounds in drinking water by liquid chromatography-tandem mass spectrometry].
作者信息
Hu Xiaojian, Zhang Haijing, Wang Xiaohong, Ding Changming, Lin Shaobin
出版信息
Wei Sheng Yan Jiu. 2015 May;44(3):427-30.
OBJECTIVE
To simultaneously determine the four bisphenolic compounds (bisphenol F, bisphenol A, tetrachlorobisphenol A and tetrabromobisphenol A) in drinking water by liquid chromatography tandem mass spectrometry.
METHODS
200 ml water sample was extracted by solid-phase extraction, eluted with methanol and analyzed by liquid chromatography tandem mass spectrometry under the MRM mode. The separation was carried out on a T3 column (2.1 mm x 150 mm, 3 μm).
RESULTS
The limits of detection for the four bisphenolic compounds were in the range of 0.20 - 5.5 ng/L. The mean recoveries at the two spiked levels were 87.1% - 109.0% with the intra-day precision between 6.3% - 12.4% and inter-day precision between 4.5% - 15.4%. The method was applied for determination of 15 water samples.
CONCLUSION
The method was sensitive, precise and accurate.
目的
采用液相色谱串联质谱法同时测定饮用水中的四种双酚类化合物（双酚F、双酚A、四氯双酚A和四溴双酚A）。
方法
取200 ml水样，采用固相萃取法进行萃取，用甲醇洗脱，在多反应监测（MRM）模式下采用液相色谱串联质谱法进行分析。分离在T3柱（2.1 mm×150 mm，3μm）上进行。
结果
四种双酚类化合物的检测限在0.20 - 5.5 ng/L范围内。两个加标水平下的平均回收率为87.1% - 109.0%，日内精密度在6.3% - 12.4%之间，日间精密度在4.5% - 15.4%之间。该方法应用于15个水样的测定。
结论
该方法灵敏、准确、精密。
Zotero 插件