Sahay A S, Sundrani D P, Wagh G N, Mehendale S S, Joshi S R
Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India.
Department of Obstetrics and Gynecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune, India.
Placenta. 2015 Aug;36(8):938-43. doi: 10.1016/j.placenta.2015.06.006. Epub 2015 Jun 22.
Our recent study in preeclampsia indicates differential oxidative stress in various regions of the placenta. Oxidative stress is known to influence neurotrophin levels. We therefore hypothesize that placental regional differences in oxidative stress will also lead to differences in neurotrophin levels.
The current study examines the levels of neurotrophins, brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in different regions of the placenta in 50 normotensive control women and 47 women with preeclampsia (21 delivering at term and 26 delivering preterm). Placentae were collected from four different regions: central maternal (CM), central fetal (CF), peripheral maternal (PM) and peripheral fetal (PF).
BDNF levels were higher in CF region as compared to CM (p < 0.01), PM (p < 0.01) and PF (p < 0.05) regions of the placenta in the control group. There was no regional change in NGF levels in any of the groups. Analysis between groups indicated higher NGF levels in CM (p < 0.01), PM (p < 0.05) and PF (p < 0.01) regions of preterm preeclampsia group as compared to control. Negative association of NGF levels in CM, CF and PM regions with baby weight and in CF, PM and PF regions with baby length was observed. NGF levels in all four regions were positively associated with systolic blood pressure.
Our data indicates regional differences in levels of BDNF only in normotensive control but not in preeclampsia group. Higher NGF levels in preterm preeclampsia may be a response to increased oxidative stress. This may have implications for altered placental development in preeclampsia.
我们最近关于子痫前期的研究表明，胎盘不同区域存在差异性氧化应激。已知氧化应激会影响神经营养因子水平。因此，我们推测胎盘氧化应激的区域差异也会导致神经营养因子水平的差异。
本研究检测了50名血压正常的对照女性和47名单纯性子痫前期女性（21名足月分娩，26名早产）胎盘不同区域的神经营养因子、脑源性神经营养因子（BDNF）和神经生长因子（NGF）水平。胎盘取自四个不同区域：中央母体区（CM）、中央胎儿区（CF）、外周母体区（PM）和外周胎儿区（PF）。
在对照组中，胎盘CF区域的BDNF水平高于CM区域（p < 0.01）、PM区域（p < 0.01）和PF区域（p < 0.05）。所有组的NGF水平均无区域变化。组间分析表明，与对照组相比，早产子痫前期组的CM区域（p < 0.01）、PM区域（p < 0.05）和PF区域（p < 0.01）的NGF水平更高。观察到CM、CF和PM区域的NGF水平与出生体重呈负相关，CF、PM和PF区域的NGF水平与出生身长呈负相关。所有四个区域的NGF水平均与收缩压呈正相关。
我们的数据表明，仅在血压正常的对照组中BDNF水平存在区域差异，而子痫前期组中不存在。早产子痫前期中较高的NGF水平可能是对氧化应激增加的一种反应。这可能对子痫前期胎盘发育改变具有影响。
