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人类脾脏对红细胞的机械清除作用:一种仿生红细胞过滤方法的潜在治疗应用。

Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method.

作者信息

Duez J, Holleran J P, Ndour P A, Pionneau C, Diakité S, Roussel C, Dussiot M, Amireault P, Avery V M, Buffet P A

机构信息

CIMI-Paris U1135, équipe 4, hôpital La Pitié-Salpêtrière, 75013 Paris, France; Laboratoire d'excellence GR-Ex, 24, boulevard du Montparnasse, 75015, Paris, France; HRA Pharma Laboratoires, 15, rue de Béranger, 75003 Paris, France; Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.

Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, QLD 4111, Australia.

出版信息

Transfus Clin Biol. 2015 Aug;22(3):151-7. doi: 10.1016/j.tracli.2015.05.004. Epub 2015 Jun 29.

Abstract

During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion.

摘要

在其生命周期内,循环红细胞的可变形性会经常受到检查。这种机械质量控制主要在人类脾脏中进行。无法通过狭窄脾窦的红细胞会被滞留并从血液循环中清除。在生理条件下,这可防止微血管被衰老、僵硬的红细胞堵塞。可变形性差的红细胞的滞留是疟疾发病机制的一个重要决定因素,也可能影响输血的临床效果。调节红细胞的脾脏滞留已被提议用于支持这些研究领域的治疗方法。为此,已经开展了通过微球层对红细胞进行高通量过滤的微孔板(基于微孔板的微球过滤)的开发。本综述重点关注该技术在疟疾化疗和输血方面的潜在治疗应用。

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