Roussey M, Libeau B, Le Marec B, Odent S, Poulain P, Giraud J R, Sénécal J, Jouan H, Milon J, Picard F
Service de Pédiatrie-Génétique médicale, Hôpital Pontchaillou, C.H.U. Rennes.
J Gynecol Obstet Biol Reprod (Paris). 1989;18(7):941-9.
The authors have made the census of all the Medical Terminations of Pregnancy (MTP) which have been carried out in the Department of Ille et Vilaine from 1982 to 1986, i.e. 222 cases, in order to precise the different indications and the diagnosis tools which were used. 132 MTP concern women who live in the Department of Ille et Vilaine. By referring this figure to the total number of pregnancies in this area, one can see that the average incidence is of 1.9%; MTP account for 1% of the total number of Terminations of Pregnancies. Foetal indications are more frequent (188 cases; i.e. 84.7%) than maternal ones (34 cases, 15.3%); these figures remained stable over the 5-year period of study. Chromosomal aberrations and closing defects of the neural tubule are the main causes of MTP (22.9% of foetal indications). Among the 43 chromosomal aberrations, trisomies are the most frequent ones (34.9%) because all women aged 38 or more are proposed a detection. The diagnosis of trisomy was made in 24 cases after tests were programmed either because of the age of the mother or because of family antecedents (amniocentesis: 22 times, punction of foetal blood: once, biopsy of chorion villosities: once), in 6 cases after tests were carried out on the basis of suspect clinical signs amniocentesis: once, punction of foetal blood: 5 times), and in 13 cases after the echography had revealed a major syndrome. Closing defects of the central nervous system mainly concern anencephaly (17.6% of foetal indications) since the echography enables an easy diagnosis. All anencephaly have actually been detected during the reference period of pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
作者对1982年至1986年期间在伊勒-维莱讷省进行的所有人工流产（MTP）进行了普查，共计222例，以明确不同的指征和所使用的诊断工具。132例人工流产涉及居住在伊勒-维莱讷省的女性。将这一数字与该地区的总妊娠数相比，可以看出平均发生率为1.9%；人工流产占妊娠终止总数的1%。胎儿指征比母亲指征更常见（188例，即84.7%），而母亲指征为34例（15.3%）；在5年的研究期间，这些数字保持稳定。染色体畸变和神经管闭合缺陷是人工流产的主要原因（占胎儿指征的22.9%）。在43例染色体畸变中，三体最为常见（34.9%），因为所有38岁及以上的女性都被建议进行检测。由于母亲年龄或家族病史而安排检查后，24例确诊为三体（羊膜穿刺术：22次，胎儿采血：1次，绒毛膜绒毛活检：1次）；基于可疑临床体征进行检查后，6例确诊为三体（羊膜穿刺术：1次，胎儿采血：5次）；超声检查发现主要综合征后，13例确诊为三体。中枢神经系统闭合缺陷主要涉及无脑儿（占胎儿指征的17.6%），因为超声检查能够轻松诊断。实际上，所有无脑儿均在孕期参考期内被检测到。（摘要截断于250字）
