眼表上皮干细胞的最新进展：角膜与结膜
An Update on Ocular Surface Epithelial Stem Cells: Cornea and Conjunctiva.
作者信息
Ramos Tiago, Scott Deborah, Ahmad Sajjad
机构信息
Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 3GA, UK.
Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 3GA, UK ; St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.
出版信息
Stem Cells Int. 2015;2015:601731. doi: 10.1155/2015/601731. Epub 2015 Jun 4.
Abstract
The human ocular surface (front surface of the eye) is formed by two different types of epithelia: the corneal epithelium centrally and the conjunctival epithelium that surrounds this. These two epithelia are maintained by different stem cell populations (limbal stem cells for the corneal epithelium and the conjunctival epithelial stem cells). In this review, we provide an update on our understanding of these epithelia and their stem cells systems, including embryology, new markers, and controversy around the location of these stem cells. We also provide an update on the translation of this understanding into clinical applications for the treatment of debilitating ocular surface diseases.
摘要
人眼表面（眼睛的前表面）由两种不同类型的上皮组织构成：中央的角膜上皮和环绕其的结膜上皮。这两种上皮组织由不同的干细胞群体维持（角膜上皮由角膜缘干细胞维持，结膜上皮由结膜上皮干细胞维持）。在本综述中，我们更新了对这些上皮组织及其干细胞系统的认识，包括胚胎学、新标志物以及围绕这些干细胞位置的争议。我们还更新了将这一认识转化为治疗使人衰弱的眼表疾病临床应用的相关内容。
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