胡椒碱介导合成、表征、氧化铜纳米粒子的抗菌和大鼠脾细胞细胞毒性作用。
Piper betle-mediated synthesis, characterization, antibacterial and rat splenocyte cytotoxic effects of copper oxide nanoparticles.
机构信息
a Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University , Iksan , South Korea.
b PG & Research Department of Biotechnology , Mahendra Arts and Science College , Kalippatti, Namakkal , Tamil Nadu , India.
出版信息
Artif Cells Nanomed Biotechnol. 2016 Sep;44(6):1400-5. doi: 10.3109/21691401.2015.1029630. Epub 2015 Jul 6.
The study reports a simple, inexpensive, and eco-friendly synthesis of copper oxide nanoparticles (CuONPs) using Piper betle leaf extract. Formation of CuONPs was confirmed by UV-visible spectroscopy at 280 nm. Transmission electron microscopy (TEM) images showed that the CuONPs were spherical, with an average size of 50-100 nm. The scanning electron microscopy (SEM)-energy dispersive spectroscopy (EDS) peak was observed approximately at 1 and 8 keV. The X-ray diffraction (XRD) studies indicated that the particles were crystalline in nature. CuONPs effectively inhibited the growth of phytopathogens Ralstonia solanacearum and Xanthomonas axonopodis. The cytotoxic effect of the synthesized CuONPs was analyzed using rat splenocytes. The cell viability was decreased to 94% at 300 μg/mL.
该研究报告了一种使用菝葜叶提取物合成氧化铜纳米粒子（CuONPs）的简单、廉价和环保方法。通过在 280nm 处的紫外-可见光谱证实了 CuONPs 的形成。透射电子显微镜（TEM）图像显示，CuONPs 呈球形，平均粒径为 50-100nm。扫描电子显微镜（SEM）-能谱（EDS）峰约在 1 和 8keV 处观察到。X 射线衍射（XRD）研究表明，这些颗粒具有晶体性质。CuONPs 有效抑制了植物病原菌青枯菌和黄单胞菌的生长。使用大鼠脾细胞分析了合成的 CuONPs 的细胞毒性作用。当浓度为 300μg/mL 时，细胞活力下降到 94%。
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