镧系掺杂 LiGdF4 纳米颗粒在 LiLuF4 核作用下的生长作为三模态成像生物探针。
Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes.
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Biomaterials. 2015 Oct;65:115-23. doi: 10.1016/j.biomaterials.2015.06.023. Epub 2015 Jun 15.
Multimodal imaging can compensate for the deficiencies and incorporate the advantages of individual imaging modalities. In this paper, we demonstrated the synthesis of core-shell nanocomposites LiLuF4@LiGdF4:Yb,Er/Tm constituted of tetragonal LiLuF4 nanoparticles as core and Yb,Er/Tm-codoped LiGdF4 as shell. LiLuF4@LiGdF4:Yb,Er/Tm nanoparticles display brighter upconversion luminescence (UCL) than NaGdF4:Yb,Er/Tm nanoparticles with the same size under continuous-wave excitation at 980 nm. The active shell layer of LiGdF4:Yb,Er/Tm not only provide the UCL center, but also serve as magnetic resonance (MR) imaging contrast agent. To further improve the UCL intensity, the inert LiGdF4 shell was coated on the LiLuF4@LiGdF4:Yb,Er/Tm nanoparticles. Furthermore, LiLuF4@LiGdF4:Yb,Tm@LiGdF4 nanoparticles have been successfully applied to UCL/X-ray computed tomography (CT)/MR tri-modal imaging on the modal of tumor-bearing mice.
多模态成像是对单一模态成像的补充，可以发挥其各自的优势。本文采用四方相 LiLuF4 纳米晶作为核，Yb,Er/Tm 共掺杂的 LiGdF4 作为壳，合成了核壳结构的 LiLuF4@LiGdF4:Yb,Er/Tm 纳米复合材料。与具有相同尺寸的 NaGdF4:Yb,Er/Tm 纳米晶相比，在 980nm 连续波激发下，LiLuF4@LiGdF4:Yb,Er/Tm 纳米晶表现出更亮的上转换发光（UCL）。LiGdF4:Yb,Er/Tm 的活性壳层不仅提供了 UCL 中心，而且还可用作磁共振（MR）成像造影剂。为了进一步提高 UCL 强度，将惰性 LiGdF4 壳层包覆在 LiLuF4@LiGdF4:Yb,Er/Tm 纳米晶上。此外，我们还成功地将 LiLuF4@LiGdF4:Yb,Tm@LiGdF4 纳米颗粒应用于荷瘤小鼠模型的 UCL/ X 射线计算机断层扫描（CT）/MR 三模态成像。
Zotero 插件