Chen Yanan, Zhao Qinghua
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Front Bioeng Biotechnol. 2025 Apr 28;13:1591896. doi: 10.3389/fbioe.2025.1591896. eCollection 2025.
Osteoporosis, a prevalent systemic metabolic bone disease, is characterized by diminished bone mass, microarchitectural deterioration of bone tissue, and heightened bone fragility. In osteoporotic patients, chronic and progressive bone loss often leads to fractures and, in advanced cases, critical-sized bone defects. While traditional bone repair approaches are constrained by significant limitations, the advent of bioactive scaffolds has transformed the therapeutic paradigm for osteoporotic bone regeneration. Among these innovations, natural polymer-based hydrogel scaffolds have emerged as a particularly promising solution in bone tissue engineering, owing to their superior biocompatibility, tunable biodegradation properties, and exceptional ability to replicate the native extracellular matrix environment. This review systematically explores recent breakthroughs in modification techniques and therapeutic applications of natural hydrogel scaffolds for osteoporotic bone defect repair, while critically analyzing existing clinical challenges and proposing future research trajectories in this rapidly evolving field.
骨质疏松症是一种常见的全身性代谢性骨病，其特征是骨量减少、骨组织微结构退化以及骨脆性增加。在骨质疏松症患者中，慢性进行性骨质流失常导致骨折，在晚期病例中还会出现临界尺寸的骨缺损。虽然传统的骨修复方法存在重大局限性，但生物活性支架的出现改变了骨质疏松性骨再生的治疗模式。在这些创新中，基于天然聚合物的水凝胶支架因其卓越的生物相容性、可调节的生物降解特性以及复制天然细胞外基质环境的特殊能力，已成为骨组织工程中特别有前景的解决方案。本综述系统地探讨了天然水凝胶支架用于骨质疏松性骨缺损修复的改性技术和治疗应用的最新突破，同时批判性地分析了现有的临床挑战，并提出了在这个快速发展的领域未来的研究方向。
