Nishimura K, Hazato T
Masui. 1989 Jul;38(7):888-90.
By the use of high performance liquid chromatography and a specific radioimmunoassay method combined with a new dialysis technique, plasma levels of leu-enkephalin were determined in 26 women who had become pregnant normally, some of whom were in 5 to 40 weeks gestation and the others were 3 days postpartum. Leu-enkephalin-like immunoactivity rose during 5-6 weeks gestation (982.0 +/- 388.3pg.ml-1) and 3 days after delivery (594.4 +/- 289.2pg.ml-1). This pattern differed significantly from that of the normal adult control groups (174.9 +/- 75.3pg.ml-1). The concentrations of serum leu-enkephalin during 10-40 weeks of gestation were within normal limits. These results indicate that the serum leu-enkephalin concentrations increase in the early stage of pregnancy. Whereas the physiological mechanism and exact meaning of this change are still unknown, the results strongly suggest that this substance has an important part to play in such physiological functions as pregnancy.
通过使用高效液相色谱法以及一种特定的放射免疫测定方法，并结合一种新的透析技术，对26名正常怀孕的女性的血浆亮氨酸脑啡肽水平进行了测定，其中一些女性处于妊娠5至40周，另一些则是产后3天。亮氨酸脑啡肽样免疫活性在妊娠5至6周（982.0±388.3pg.ml-1）以及分娩后3天（594.4±289.2pg.ml-1）时升高。这种模式与正常成人对照组（174.9±75.3pg.ml-1）有显著差异。妊娠10至40周期间血清亮氨酸脑啡肽的浓度在正常范围内。这些结果表明，妊娠早期血清亮氨酸脑啡肽浓度会升高。尽管这种变化的生理机制和确切意义仍不清楚，但这些结果有力地表明，这种物质在诸如妊娠等生理功能中起着重要作用。
