[无嘌呤饮食后，正常受试者和痛风患者血浆及尿液中嘌呤的行为]

[Behavior of plasma and urine purines, after a purine-free diet, in normal subjects and patients with gout].

作者信息

Vannoni D, Porcelli B, Di Stefano A, Pizzichini M, Leoncini R, Terzuoli L, Taddeo A, Marsini S, Morozzi G, Marcolongo R

出版信息

Medicina (Firenze). 1989 Jul-Sep;9(3):295-7.

Abstract

Plasma and urine oxypurines (hypoxanthine and xanthine) and uric acid, were evaluated in normal subjects and in gouty patients before and after a purine free diet. After a 7-days period, plasma oxypurines were remarkably higher in normal subjects, while they did not undergo variations in gouty patients, which showed higher in basal conditions. No significant changes in urinary excretion were observed in both cases. The interpretation of the observed variations is discussed.

摘要

在正常受试者以及痛风患者中，于无嘌呤饮食前后对血浆和尿液中的氧嘌呤（次黄嘌呤和黄嘌呤）及尿酸进行了评估。经过7天的时间后，正常受试者的血浆氧嘌呤显著升高，而痛风患者的血浆氧嘌呤未发生变化，痛风患者在基础状态下的血浆氧嘌呤水平更高。在这两种情况下，均未观察到尿排泄有显著变化。对观察到的变化进行了讨论。