Vannoni D, Porcelli B, Caldarone R, Garzi A
Medicina (Firenze). 1989 Jan-Mar;9(1):51-4.
Levels of oxypurines (hypoxanthine and xanthine) and uric acid were measured in plasma and urine of tumor bearing patients (gastric and colon rectal tumors), and of subjects affected by non specific diseases. In both groups, an increase in plasma purine bases and a decrease of their excretion was observed as compared to healthy controls; no substantial variations concerning uric acid were found. Possible mechanisms inducing alterations of purine metabolism in so different conditions are discussed.
在患有肿瘤的患者(胃癌和结直肠癌)以及患有非特异性疾病的受试者的血浆和尿液中测量了氧嘌呤(次黄嘌呤和黄嘌呤)和尿酸的水平。与健康对照组相比,两组均观察到血浆嘌呤碱增加及其排泄减少;未发现尿酸有实质性变化。讨论了在如此不同的情况下诱导嘌呤代谢改变的可能机制。