不同控制性卵巢刺激方案对接受体外受精/卵胞浆内单精子注射的女性身体和心理负担的影响。

Impact of different controlled ovarian stimulation protocols on the physical and psychological burdens in women undergoing in vitro fertilization/intra cytoplasmic sperm injection.

作者信息

Mamata Deenadayal, Ray Subrat K, Pratap Kumar, Firuza Parikh, Birla Ashish Ramesh, Manish Banker

机构信息

Medical Director, Infertility Institute and Research Center, Hyderabad, Telangana, India.

Associate Director, Organon India Pvt. Ltd., Mumbai, Maharashtra, India.

出版信息

J Hum Reprod Sci. 2015 Apr-Jun;8(2):86-92. doi: 10.4103/0974-1208.158615.

DOI:10.4103/0974-1208.158615

PMID:26157299

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4477455/

Abstract

CONTEXT

Infertility treatment involves a considerable amount of physical and psychological burden which may impact the outcome.

AIM

The objective was to understand the amount of physical and psychological burden in women undergoing their first in vitro fertilization (IVF)/intra cytoplasmic sperm injection (ICSI) cycles.

SETTING AND DESIGN

Multi-center, prospective, parallel, observational study.

MATERIALS AND METHODS

The study was conducted across 12 IVF centers in India. A total of 692 women undergoing controlled ovarian stimulation as a part of the first cycle IVF/ICSI completed the trial. Women were recruited in 2 groups based on type of treatment (Group A - gonadotropin-releasing hormone [GnRH] antagonist; Group B - GnRH agonist) and were asked to fill questionnaires during the 2 treatment visits.

RESULTS

The mean changes between Visit 1 (baseline) and Visit 2 in anxiety and depression (Hospital Anxiety and Depression Scale) scores in Group A for anxiety and depression were -0.5 (3.67), -0.1 (3.57) respectively and for Group B were -0.4 (3.68), 0.1 (3.67) respectively, which was not statistically significant. In Group A, the mean (±standard deviation [SD]) Hopkins Symptom Check List (HSCL) score was 17.9 (±5.17) in visit 1 and 19.1 (±5.45) Visit 2. The change between visits was 1.1 (P < 0.0001) with higher score reflecting higher somatic distress symptoms. In Group B, the mean (±SD) HSCL score was 18.2 (±5.19) in Visit 1 and 18.8 (±5.23) in visit 2. The change between visits was 0.6 (P < 0.0014). The difference of the mean change in physical burden between Group A and Group B was not statistically significant.

CONCLUSION

A significant impact in both treatment protocols with respect to the physical burden was found between Visit 1 and Visit 2 but no difference in physical or psychological burden between the two treatment groups was observed.

摘要

背景

不孕治疗会带来相当大的身体和心理负担，这可能会影响治疗结果。

目的

目的是了解接受首次体外受精（IVF）/卵胞浆内单精子注射（ICSI）周期的女性的身体和心理负担程度。

设置与设计

多中心、前瞻性、平行、观察性研究。

材料与方法

该研究在印度的12个体外受精中心进行。共有692名接受控制性卵巢刺激作为首次IVF/ICSI周期一部分的女性完成了试验。根据治疗类型将女性分为两组（A组 - 促性腺激素释放激素[GnRH]拮抗剂；B组 - GnRH激动剂），并要求她们在两次治疗就诊时填写问卷。

结果

A组在第1次就诊（基线）和第2次就诊时焦虑和抑郁（医院焦虑抑郁量表）评分的平均变化，焦虑方面为-0.5（3.67），抑郁方面为-0.1（3.57）；B组焦虑方面为-0.4（3.68），抑郁方面为0.1（3.67），差异无统计学意义。在A组，第1次就诊时霍普金斯症状清单（HSCL）平均（±标准差[SD]）评分为17.9（±5.17），第2次就诊时为19.1（±5.45）。两次就诊之间的变化为1.1（P < 0.0001），得分越高表明躯体痛苦症状越严重。在B组，第1次就诊时HSCL平均（±SD）评分为18.2（±5.19），第2次就诊时为18.8（±5.23）。两次就诊之间的变化为0.6（P < 0.0014）。A组和B组身体负担平均变化的差异无统计学意义。