Olivius Catharina, Friden Barbro, Borg Gunilla, Bergh Christina
Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Institution for Women's and Children's Health, Sahlgrenska University Hospital, Göteborg, Sweden.
Fertil Steril. 2004 Feb;81(2):258-61. doi: 10.1016/j.fertnstert.2003.06.029.
To investigate reasons for discontinuation of IVF treatment.
Prospective, cohort study.
Center for reproductive medicine at a large university hospital.
PATIENT(S): The 450 couples of a cohort of 974 couples who started IVF treatment between January 1996 and December 1997 and did not achieve childbirth.
INTERVENTION(S): The reasons for ceasing treatment were evaluated by scrutinizing the medical records for all couples (n = 288) who did not achieve live birth and who did not complete three stimulated IVF cycles. A questionnaire was sent to all patients for whom the reason for discontinuation was not obvious from the medical records (n = 211).
MAIN OUTCOME MEASURE(S): Reasons for discontinuing IVF.
RESULT(S): Of 450 couples not achieving live birth, 208 completed their subsidized cycles, whereas 242 discontinued IVF. In 192 (79%) of the 242 cases, the reasons for ceasing treatment could be identified from records or questionnaires. The reason for discontinuation was psychological burden in 26%, a poor prognosis in 25%, spontaneous pregnancy in 19%, physical burden in 6%, serious disease in 2%, and other reasons in 7%.
CONCLUSION(S): An unexpectedly high percentage of couples who performed IVF discontinued the treatment before the three cycles that were offered to a majority of the couples. A majority of these discontinuations were due to psychological stress. This information is of importance when counseling patients during treatment.
探讨体外受精（IVF）治疗中断的原因。
前瞻性队列研究。
一所大型大学医院的生殖医学中心。
1996年1月至1997年12月开始接受IVF治疗但未分娩的974对夫妇中的450对夫妇。
通过仔细审查所有未实现活产且未完成三个刺激IVF周期的夫妇（n = 288）的病历，评估停止治疗的原因。向所有病历中停止治疗原因不明显的患者（n = 211）发送问卷。
IVF治疗中断的原因。
在450对未实现活产的夫妇中，208对完成了补贴周期，而242对停止了IVF治疗。在242例中的192例（79%）中，停止治疗的原因可从病历或问卷中确定。中断治疗的原因是心理负担占26%，预后不良占25%，自然妊娠占19%，身体负担占6%，重病占2%，其他原因占7%。
接受IVF治疗的夫妇中，有出乎意料高比例的夫妇在大多数夫妇可接受的三个周期之前就停止了治疗。这些中断中的大多数是由于心理压力。该信息在治疗期间为患者提供咨询时很重要。
