Turkmen Serdar, Buyukhatipoglu Hakan, Suner Ali, Apucu Haci Gokhan, Ulas Turgay
Department of Cardiology, Sanko University School of Medicine, Gaziantep, Turkey.
Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
Int J Crit Illn Inj Sci. 2015 Apr-Jun;5(2):114-5. doi: 10.4103/2229-5151.158416.
In this paper, we report a case of drug-induced pancreatitis just after taking a pain pill including a low-dose combination of acetaminophen and codeine. Codeine-induced pancreatitis has been rarely reported, however, well-established. The proposed mechanism for codeine-induced pancreatitis is by increasing Oddi sphincter pressure. However, the clinically important point is that the codeine-induced pancreatitis is seen almost only in the cholecystectomized patients due to lacking of its reservoir capacity. Codeine is commonly used alone or in combination in pain medicine. Therefore, it is fairly important to question whether a patient underwent cholecystectomy when a physician decides to prescribe codeine-included preparations.
在本文中，我们报告了一例在服用含对乙酰氨基酚和可待因低剂量组合的止痛片后发生药物性胰腺炎的病例。可待因诱发的胰腺炎虽鲜有报道，但已得到充分证实。可待因诱发胰腺炎的推测机制是增加Oddi括约肌压力。然而，临床上重要的一点是，由于缺乏储存能力，可待因诱发的胰腺炎几乎仅见于胆囊切除术后的患者。可待因在止痛药中常单独使用或联合使用。因此，当医生决定开含可待因的制剂时，询问患者是否接受过胆囊切除术是相当重要的。
