Borgia G, Tallarino A, Crowell J, Lambiase A, Cicciarello S, Reynaud L, Piazza M
Mycoses. 1989 Nov;32(11):584-9. doi: 10.1111/j.1439-0507.1989.tb02187.x.
The ultrastructural changes which occur during the first 24 h of mycelium to yeast transition have been studied in the dimorphic fungus Histoplasma capsulatum. A temperature shift controls mycelial to yeast transition. During the first 24 h respiratory rate, ATP and cytochrome concentration fall to very low levels. Ultrastructural observations showed that the plasma membrane became undulated and the cell wall lost its characteristic fibrous outer layer. At 8 h the ordered lamellar structure of the mitochondria was no longer apparent. 24 h after the temperature shift 70% of the cells were lysed. The remaining cells contained many cytoplasmic membrane structures; mitochondria were rarely observed. These changes are considered to be the morphological expression of the physiological events characteristic of stage one in mycelial to yeast transition.
已对二态真菌荚膜组织胞浆菌在菌丝体向酵母转变的最初24小时内发生的超微结构变化进行了研究。温度变化控制着菌丝体向酵母的转变。在最初的24小时内，呼吸速率、ATP和细胞色素浓度降至极低水平。超微结构观察表明，质膜变得起伏不平，细胞壁失去了其特征性的纤维外层。在8小时时，线粒体的有序板层结构不再明显。温度变化24小时后，70%的细胞发生裂解。剩余的细胞含有许多细胞质膜结构；很少观察到线粒体。这些变化被认为是菌丝体向酵母转变第一阶段特征性生理事件的形态学表现。
