Barcellos Cristiano Roberto, Rocha Michelle Patrocínio, Hayashida Sylvia Asaka, Dantas Wagner Silva, Dos Reis Vieira Yance Viviane, Marcondes José Antonio
Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
Gynecology Unit, University of Sao Paulo, School of Medicine, Brazil.
Hormones (Athens). 2015 Apr-Jun;14(2):251-7. doi: 10.14310/horm.2002.1584.
The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation-tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (CV) risk factors (diabetes, dyslipidemia and arterial hypertension).
Twenty-five young women with PCOS and 23 eumenorrheic women without major CV risk factors and matched for body mass index (BMI) were studied. They were subdivided according to BMI and PCOS status and comparisons were made between the PCOS and Control groups, regardless of BMI, and between the Obese and Lean groups, regardless of the presence of PCOS.
Levels of TNF-α, IL-6 and hsCRP were similar between the PCOS group and the Control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-α were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hsCRP were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively).
Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major CV risk factors.
本研究旨在评估多囊卵巢综合征(PCOS)和肥胖对无主要心血管(CV)危险因素(糖尿病、血脂异常和动脉高血压)的年轻女性循环中的低度炎症标志物——肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)和高敏C反应蛋白(hsCRP)的影响。
对25名患有PCOS的年轻女性和23名无主要CV危险因素且体重指数(BMI)匹配的月经正常女性进行研究。根据BMI和PCOS状态将她们分组,并在不考虑BMI的情况下对PCOS组和对照组进行比较,以及在不考虑是否存在PCOS的情况下对肥胖组和瘦组进行比较。
PCOS组和对照组之间的TNF-α、IL-6和hsCRP水平相似(分别为2.1对1.9 pg/ml,p = 0.397;3.8对5.7 pg/ml,p = 0.805;0.9对0.5 ng/ml,p = 0.361)。肥胖组和瘦组之间的TNF-α水平相似(2.1对1.9 pg/ml,p = 0.444)。肥胖组的IL-6和hsCRP水平高于瘦组(分别为8.7对2.0,p < 0.001;1.4对0.2 ng/ml,p < 0.001)。
肥胖而非多囊卵巢综合征会影响无主要CV危险因素的年轻女性循环中的低度炎症标志物。