体重对多囊卵巢综合征炎症标志物和胰岛素抵抗的影响。
The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome.
作者信息
Souza Dos Santos Ana Celly, Soares Nayara Pereira, Costa Eduardo Caldas, de Sá Joceline Cássia Ferrezini, Azevedo George Dantas, Lemos Telma Maria Araújo Moura
机构信息
Graduate Program in Pharmaceutical Sciences - CCS , Natal, RN , Brazil .
出版信息
Gynecol Endocrinol. 2015 Mar;31(3):225-8. doi: 10.3109/09513590.2014.976546. Epub 2014 Nov 6.
OBJECTIVE
To evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI).
METHODS
Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n = 12), II (non-eutrophic without PCOS, n = 10), III (eutrophic with PCOS, n = 8) and IV (eutrophic without PCOS, n = 10) being non-eutrophic, the overweight and obese women with BMI > 25 kg/m2 and eutrophic women with BMI < 24.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR.
RESULTS
PCOS patients showed increased levels of CRP (p < 0.01) and HOMA-IR (p < 0.01). When divided by BMI, both non-eutrophicad eutrophic PCOS showed increased CRP levels (p < 0.01) and HOMA-IR (p < 0.01). There were no differences in TNF-α and IL-6 levels between groups.
CONCLUSION
In the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass.
目的
评估不同体重指数（BMI）的多囊卵巢综合征（PCOS）女性和非PCOS女性的炎症标志物及胰岛素抵抗（IR）情况。
方法
对40名育龄女性的血清样本进行肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和C反应蛋白（CRP）检测。患者被分为四组：I组（非肥胖型PCOS患者，n = 12），II组（非肥胖型非PCOS患者，n = 10），III组（肥胖型PCOS患者，n = 8）和IV组（肥胖型非PCOS患者，n = 10），其中BMI>25 kg/m²的女性为非肥胖型，BMI<24.9 kg/m²的女性为肥胖型。采用稳态模型评估法（HOMA-IR）计算IR以进行评估。
结果
PCOS患者的CRP水平（p<0.01）和HOMA-IR（p<0.01）升高。按BMI分组时，非肥胖型和肥胖型PCOS患者的CRP水平（p<0.01）和HOMA-IR（p<0.01）均升高。各组之间TNF-α和IL-6水平无差异。
结论
在PCOS组中，无论体重如何，与对照组相比，CRP水平和IR均升高。
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