巨噬细胞的供应和需求是坏死性肉芽肿的核心。

Macrophage Supply and Demand at the Core of the Necrotic Granuloma.

机构信息

Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

出版信息

Cell Host Microbe. 2015 Jul 8;18(1):3-4. doi: 10.1016/j.chom.2015.06.014.

DOI:10.1016/j.chom.2015.06.014

PMID:26159712

Abstract

Central necrosis of granulomas is linked to progression of major diseases, including tuberculosis and atherosclerosis. In this issue of Cell Host & Microbe, Pagán et al. (2015) reveal that necrotic granulomas develop when macrophage supply is insufficient. These findings suggest augmenting macrophage availability as a therapeutic strategy in tuberculosis.

摘要

肉芽肿的中心坏死与重大疾病的进展有关，包括结核病和动脉粥样硬化。在本期《细胞宿主与微生物》中，Pagan 等人（2015）揭示了当巨噬细胞供应不足时，会形成坏死性肉芽肿。这些发现表明，增加巨噬细胞的可用性可能是治疗结核病的一种策略。