Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States.
Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Cytokine. 2019 Oct;122:154169. doi: 10.1016/j.cyto.2017.09.025. Epub 2017 Oct 5.
IL-37 is a member of the IL-1 family, but unlike most other members of this family of cytokines, it has wide-ranging anti-inflammatory properties. Initially shown to bind IL-18 binding protein and prevent IL-18-mediated inflammation, its known role has been expanded to include distinct pathways, both intracellular involving the transcription factor Smad3, and extracellular via binding to the orphan receptor IL-1R8. A number of recent publications investigating the role of IL-37 in atherosclerosis and ischemic heart disease have revealed promising therapeutic value of the cytokine. Although research concerning the role of IL-37 and its mechanism in atherosclerosis is relatively scant, there are a number of well-known atherosclerotic processes that this cytokine can mediate with the potential of modulating the disease progression itself. This review will probe in detail the effects of IL-37 on important pathological processes such as inflammation, dysregulated lipid metabolism, and apoptosis, by analyzing existing data as well as exploring the potential of this cytokine to influence these properties.
IL-37 是白细胞介素 1 家族的一员,但与该细胞因子家族的大多数其他成员不同,它具有广泛的抗炎特性。最初被证明可以结合白细胞介素 18 结合蛋白并阻止白细胞介素 18 介导的炎症,其已知作用已扩展到包括不同的途径,包括细胞内涉及转录因子 Smad3 的途径,以及通过与孤儿受体白细胞介素 1R8 结合的细胞外途径。最近的一些研究表明,白细胞介素 37 在动脉粥样硬化和缺血性心脏病中的作用具有有希望的治疗价值。尽管有关白细胞介素 37 在动脉粥样硬化中的作用及其机制的研究相对较少,但该细胞因子可以介导许多已知的动脉粥样硬化过程,有可能调节疾病本身的进展。通过分析现有数据以及探讨该细胞因子影响这些特性的潜力,本文详细探讨了白细胞介素 37 对炎症、脂质代谢失调和细胞凋亡等重要病理过程的影响。