Suppr超能文献

IL-37 在动脉粥样硬化中的潜在作用。

Potential role of IL-37 in atherosclerosis.

机构信息

Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States.

Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.

出版信息

Cytokine. 2019 Oct;122:154169. doi: 10.1016/j.cyto.2017.09.025. Epub 2017 Oct 5.

Abstract

IL-37 is a member of the IL-1 family, but unlike most other members of this family of cytokines, it has wide-ranging anti-inflammatory properties. Initially shown to bind IL-18 binding protein and prevent IL-18-mediated inflammation, its known role has been expanded to include distinct pathways, both intracellular involving the transcription factor Smad3, and extracellular via binding to the orphan receptor IL-1R8. A number of recent publications investigating the role of IL-37 in atherosclerosis and ischemic heart disease have revealed promising therapeutic value of the cytokine. Although research concerning the role of IL-37 and its mechanism in atherosclerosis is relatively scant, there are a number of well-known atherosclerotic processes that this cytokine can mediate with the potential of modulating the disease progression itself. This review will probe in detail the effects of IL-37 on important pathological processes such as inflammation, dysregulated lipid metabolism, and apoptosis, by analyzing existing data as well as exploring the potential of this cytokine to influence these properties.

摘要

IL-37 是白细胞介素 1 家族的一员,但与该细胞因子家族的大多数其他成员不同,它具有广泛的抗炎特性。最初被证明可以结合白细胞介素 18 结合蛋白并阻止白细胞介素 18 介导的炎症,其已知作用已扩展到包括不同的途径,包括细胞内涉及转录因子 Smad3 的途径,以及通过与孤儿受体白细胞介素 1R8 结合的细胞外途径。最近的一些研究表明,白细胞介素 37 在动脉粥样硬化和缺血性心脏病中的作用具有有希望的治疗价值。尽管有关白细胞介素 37 在动脉粥样硬化中的作用及其机制的研究相对较少,但该细胞因子可以介导许多已知的动脉粥样硬化过程,有可能调节疾病本身的进展。通过分析现有数据以及探讨该细胞因子影响这些特性的潜力,本文详细探讨了白细胞介素 37 对炎症、脂质代谢失调和细胞凋亡等重要病理过程的影响。

相似文献

1
Potential role of IL-37 in atherosclerosis.
Cytokine. 2019 Oct;122:154169. doi: 10.1016/j.cyto.2017.09.025. Epub 2017 Oct 5.
2
IL-37-a putative therapeutic agent in cardiovascular diseases.
QJM. 2022 Nov 14;115(11):719-725. doi: 10.1093/qjmed/hcab011.
3
The family of the interleukin-1 receptors.
Immunol Rev. 2018 Jan;281(1):197-232. doi: 10.1111/imr.12606.
4
Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8.
Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2497-502. doi: 10.1073/pnas.1424626112. Epub 2015 Feb 5.
5
Transgenic Overexpression of IL-37 Protects Against Atherosclerosis and Strengthens Plaque Stability.
Cell Physiol Biochem. 2018;45(3):1034-1050. doi: 10.1159/000487344. Epub 2018 Feb 7.
6
The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases.
Cytokine. 2015 Nov;76(1):25-37. doi: 10.1016/j.cyto.2015.06.017. Epub 2015 Jul 13.
7
The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.
Atherosclerosis. 2018 Feb;269:262-271. doi: 10.1016/j.atherosclerosis.2017.12.027. Epub 2017 Dec 25.
8
9
Therapeutic potential of targeting IL-1 and IL-18 in inflammation.
Expert Opin Biol Ther. 2004 Jun;4(6):847-60. doi: 10.1517/14712598.4.6.847.
10
The IL-1 cytokine family and its role in inflammation and fibrosis in the lung.
Semin Immunopathol. 2016 Jul;38(4):517-34. doi: 10.1007/s00281-016-0559-z. Epub 2016 Mar 21.

引用本文的文献

2
Potential Role of IL-37 in Atopic Dermatitis.
Cells. 2023 Dec 4;12(23):2766. doi: 10.3390/cells12232766.
3
Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients.
Int J Gen Med. 2023 Jul 12;16:2987-2997. doi: 10.2147/IJGM.S417471. eCollection 2023.
5
The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells.
PLoS One. 2023 Feb 8;18(2):e0280741. doi: 10.1371/journal.pone.0280741. eCollection 2023.
6
The IL-1 Family and Its Role in Atherosclerosis.
Int J Mol Sci. 2022 Dec 20;24(1):17. doi: 10.3390/ijms24010017.
7
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria.
BMC Infect Dis. 2021 Oct 18;21(1):1073. doi: 10.1186/s12879-021-06751-y.
9
Clinical Implications of IL-32, IL-34 and IL-37 in Atherosclerosis: Speculative Role in Cardiovascular Manifestations of COVID-19.
Front Cardiovasc Med. 2021 Aug 6;8:630767. doi: 10.3389/fcvm.2021.630767. eCollection 2021.

本文引用的文献

2
Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Sci Immunol. 2017 Feb 10;2(8). doi: 10.1126/sciimmunol.aaj1548.
3
AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE mice.
J Lipid Res. 2017 Aug;58(8):1536-1547. doi: 10.1194/jlr.M073270. Epub 2017 Jun 13.
4
Role of NLRP3 Inflammasomes in Atherosclerosis.
J Atheroscler Thromb. 2017 May 1;24(5):443-451. doi: 10.5551/jat.RV17001. Epub 2017 Mar 4.
5
Interleukin-37 elevation in patients with atrial fibrillation.
Clin Cardiol. 2017 Feb;40(2):66-72. doi: 10.1002/clc.22630. Epub 2016 Nov 2.
6
Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice.
Cytokine. 2017 Jul;95:55-63. doi: 10.1016/j.cyto.2017.02.008. Epub 2017 Feb 24.
7
Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis.
Circ Res. 2017 Feb 17;120(4):713-735. doi: 10.1161/CIRCRESAHA.116.309326.
9
10
The Role of Efferocytosis in Atherosclerosis.
Circulation. 2017 Jan 31;135(5):476-489. doi: 10.1161/CIRCULATIONAHA.116.025684.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验