锂对大鼠海马体中突触前5-羟色胺自身受体的失活作用。

Inactivation of presynaptic 5-HT autoreceptors by lithium in rat hippocampus.

作者信息

Hide I, Yamawaki S

机构信息

Department of Psychiatry and Neuroscience, Kure National Hospital, Hiroshima, Japan.

出版信息

Neurosci Lett. 1989 Dec 15;107(1-3):323-6. doi: 10.1016/0304-3940(89)90839-2.

DOI:10.1016/0304-3940(89)90839-2

PMID:2616042

Abstract

The effect of lithium ion on the electrically stimulated 5-[3H]hydroxytryptamine (5-HT) release from the rat hippocampal slices preloaded with [3H]5-HT was studied. Electrically stimulated [3H]5-HT release decreased when the slices were exposed to 5-HT in a concentration-dependent manner. Lithium (2.5 mM) did not affect [3H]5-HT release when added alone to the superfusion medium. However, the inhibitory effect of 5-HT (1 microM) on [3H]5-HT release was abolished by lithium. The results suggest that lithium may inhibit the regulation of 5-HT release via presynaptic 5-HT autoreceptors in rat hippocampus.

摘要

研究了锂离子对预先加载[³H]5-羟色胺（5-HT）的大鼠海马切片经电刺激后5-[³H]羟色胺（5-HT）释放的影响。当切片以浓度依赖性方式暴露于5-HT时，电刺激的[³H]5-HT释放减少。单独添加到灌流培养基中的锂（2.5 mM）不影响[³H]5-HT释放。然而，锂消除了5-HT（1 microM）对[³H]5-HT释放的抑制作用。结果表明，锂可能通过大鼠海马中突触前5-HT自身受体抑制5-HT释放的调节。