Urtizberea M, Bourre J M, Debray M, Scherrmann J M
INSERM U 26 Hôpital Fernand Widal, Paris, France.
Neurotoxicology. 1989 Summer;10(2):211-7.
The administration of colchicine to dysmyelinating mutant mice may serve as an in vivo pharmacological tool for the study of the mechanisms involved in the formation of the myelin sheath. The study of the acute toxicity of colchicine in these mutants demonstrated that male animals were much more sensitive than female animals. All of the mutants and their controls were also more resistant to colchicine than the Swiss strain usually used in toxicity studies.
给脱髓鞘突变小鼠施用秋水仙碱可作为一种体内药理学工具，用于研究髓鞘形成所涉及的机制。对这些突变体中秋水仙碱的急性毒性研究表明，雄性动物比雌性动物更敏感。所有突变体及其对照对秋水仙碱的耐受性也高于毒性研究中常用的瑞士品系。
