Sougawa M, Tanaka Y
Nihon Igaku Hoshasen Gakkai Zasshi. 1989 Oct 25;49(10):1298-303.
We have evaluated the effect of nucleoside related compounds on a murine tumor given with local radiotherapy and on the survival rate following whole body irradiation. C3H/He mouse transplanted FM3A tumor and ddY mice were used. The enhancement ratio (ER) for the tumor treated by radiation and nucleoside related compounds was 1.02-1.67. For the normal tissue, Ara-A and BVAU given with radiation had no effect on the survival rate. In the combination of 50-800 mg/kg of ACV and whole body irradiation, the 50% survival day after 7 Gy was shorter than that of radiation alone. When 25-400 mg/kg of 3'-dG was given with radiation, the 50% survival day was longer. When combined with radiation, LD50/30 for ACV and 3'-dG were 3.9 and 6.3 Gy, respectively. ACV showed radiosensitizing effect with Dose modifying factor (DMF) at 1.1, on the other hand, 3'-dG showed radioprotective effect with DMF at 1.47. Our results suggested that some nucleoside analogues might be useful as radiosensitizer.
我们评估了核苷相关化合物对局部放疗的小鼠肿瘤以及全身照射后的存活率的影响。使用了移植FM3A肿瘤的C3H/He小鼠和ddY小鼠。放疗与核苷相关化合物联合处理的肿瘤的增强比（ER）为1.02 - 1.67。对于正常组织，放疗时给予阿糖腺苷（Ara - A）和BVAU对存活率没有影响。在50 - 800 mg/kg阿昔洛韦（ACV）与全身照射联合使用时，7 Gy照射后50%存活天数比单纯放疗组短。当放疗时给予25 - 400 mg/kg的3'-脱氧鸟苷（3'-dG），50%存活天数延长。与放疗联合时，阿昔洛韦和3'-脱氧鸟苷的30天半数致死剂量（LD50/30）分别为3.9 Gy和6.3 Gy。阿昔洛韦表现出放射增敏作用，剂量修正因子（DMF）为1.1，另一方面，3'-dG表现出放射保护作用，DMF为1.47。我们的结果表明，一些核苷类似物可能可用作放射增敏剂。
