Kim Ho Soong, Yang Heon, Lee Tae Heon, Lee Kyung Heon
Sungmo Eye Hospital, Busan, Korea.
J Glaucoma. 2016 Jun;25(6):472-6. doi: 10.1097/IJG.0000000000000285.
To determine the diagnostic value of the ganglion cell-inner plexiform layer (GCIPL) thickness in glaucomatous eyes with superior or inferior visual hemifield defects.
Eighty-five patients with glaucoma (42 isolated superior hemifield defects and 43 isolated inferior hemifield defects) and 46 normal subjects were enrolled. All patients underwent Cirrus high-definition optical coherence tomography and standard automated perimetry. The area under the receiver operating characteristic curve (AUC) was calculated to determine the diagnostic ability of the GCIPL and peripapillary retinal nerve fiber layer (pRNFL).
In the superior hemifield defect glaucoma group, the best parameters for discriminating normal eyes from glaucomatous eyes were the inferotemporal GCIPL thickness (0.942), inferior quadrant RNFL thickness (0.974), and 7 o'clock sector RNFL thickness (0.999). For diagnosing inferior hemifield defect glaucoma, the AUCs of all GCIPL parameters (0.331 to 0.702) were significantly lower than that of the superior quadrant RNFL thickness (0.866, P<0.05).
The diagnostic ability of GCIPL parameters was similar to that of the pRNFL parameters in superior hemifield defect glaucoma. However, the diagnostic performance of the GCIPL parameters was significantly inferior to those of the pRNFL parameters in eyes with inferior hemifield defect glaucoma.
确定神经节细胞-内网状层（GCIPL）厚度在患有上半视野缺损或下半视野缺损的青光眼眼中的诊断价值。
纳入85例青光眼患者（42例孤立性上半视野缺损和43例孤立性下半视野缺损）和46例正常受试者。所有患者均接受了Cirrus高清光学相干断层扫描和标准自动视野检查。计算受试者操作特征曲线（AUC）下的面积，以确定GCIPL和视乳头周围视网膜神经纤维层（pRNFL）的诊断能力。
在上半视野缺损青光眼组中，区分正常眼与青光眼眼的最佳参数是颞下GCIPL厚度（0.942）、下象限RNFL厚度（0.974）和7点钟扇形RNFL厚度（0.999）。对于诊断下半视野缺损青光眼，所有GCIPL参数的AUC（0.331至0.702）均显著低于上象限RNFL厚度的AUC（0.866，P<0.05）。
在上半视野缺损青光眼中，GCIPL参数的诊断能力与pRNFL参数相似。然而，在患有下半视野缺损青光眼的眼中，GCIPL参数的诊断性能明显低于pRNFL参数。
