Gadan M A, González S J, Batalla M, Olivera M S, Policastro L, Sztejnberg M L
National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina.
National Atomic Energy Commission (CNEA), Avenida Del Libertador, 8250 Ciudad de Buenos Aires, Argentina; National Council of Scientific and Technological Research (CONICET), Avenida Rivadavia, 1970 Ciudad de Buenos Aires, Argentina.
Appl Radiat Isot. 2015 Oct;104:155-9. doi: 10.1016/j.apradiso.2015.07.006. Epub 2015 Jul 3.
In the frame of the Argentine BNCT Project a new research line has been started to study the application of BNCT to the treatment of locoregional recurrences of HER2+ breast cancer subtype. Based on former studies, the strategy considers the use of immunoliposomes as boron carriers nanovehicles to target HER2 overexpressing cells. The essential concerns of the current stage of this proposal are the development of carriers that can improve the efficiency of delivery of boron compounds and the dosimetric assessment of treatment feasibility. For this purpose, an specific pool of clinical cases that can benefit from this application was determined. In this work, we present the proposal and the advances related to the different stages of current research.
在阿根廷硼中子俘获疗法（BNCT）项目框架内，已启动一条新的研究路线，以研究BNCT在治疗HER2 +乳腺癌亚型局部区域复发中的应用。基于先前的研究，该策略考虑使用免疫脂质体作为硼载体纳米载体来靶向HER2过表达细胞。该提议当前阶段的主要关注点是开发能够提高硼化合物递送效率的载体以及治疗可行性的剂量学评估。为此，确定了可从该应用中受益的特定临床病例库。在这项工作中，我们展示了该提议以及与当前研究不同阶段相关的进展。
