[多系统萎缩伴认知功能障碍患者的1H质子磁共振波谱分析]

[1H-proton magnetic resonance spectroscopy in patients with multiple system atrophy and  cognitive dysfunction].

作者信息

Xiang Xiaoshuang, Hou Xuan, Sun Zhanfang, Zhou Gaofeng, Tang Beisha, Jiang Hong

机构信息

Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008;Department of Neurology, Xiangxi Autonomous Prefecture People's Hospital, Jishou Hunan 416000, China.

Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Jun;40(6):639-45. doi: 10.11817/j.issn.1672-7347.2015.06.011.

DOI:10.11817/j.issn.1672-7347.2015.06.011

PMID:26164513

Abstract

OBJECTIVE

To detect metabolic changes of bilateral frontal lobe in patients with multiple system atrophy (MSA) and cognitive dysfunction by 1H-proton magnetic resonance spectroscopy (1H-MRS).

METHODS

N-acetylaspartate (NAA)/creatine(Cr), choline (Cho)/Cr, myoinositol (mI)/Cr in three sides of frontal lobe were detected by 1H-MRS in 48 healthy controls, 23 patients with MSA and cognitive dysfunction and 19 patients with MSA but without cognitive dysfunction.

RESULTS

NAA/Cr of bilateral frontal lobes in patients with MSA and cognitive dysfunction was significantly decreased compared with MSA patients without cognitive dysfunction and healthy controls (P<0.05). mI/Cr of right frontal lobes was significantly increased in patients with MSA and cognitive dysfunction compared with healthy controls (P<0.05). There was a negative correlation between NAA/Cr of bilateral frontal lobes and duration while a positive correlation between NAA/Cr of bilateral frontal lobes and MoCA score in patients with MSA and cognitive dysfunction.

CONCLUSION

There is a decrease in NAA/Cr and an increase in mI/Cr in frontal lobes in patients with MSA and cognitive dysfunction, which may be associated with cognitive dysfunction in MSA patients.

摘要

目的

采用氢质子磁共振波谱（1H-MRS）检测多系统萎缩（MSA）伴认知功能障碍患者双侧额叶的代谢变化。

方法

采用1H-MRS检测48例健康对照者、23例MSA伴认知功能障碍患者和19例MSA但无认知功能障碍患者额叶三个部位的N-乙酰天门冬氨酸（NAA）/肌酸（Cr）、胆碱（Cho）/Cr、肌醇（mI）/Cr。

结果

MSA伴认知功能障碍患者双侧额叶的NAA/Cr较MSA无认知功能障碍患者和健康对照者显著降低（P<0.05）。MSA伴认知功能障碍患者右侧额叶的mI/Cr较健康对照者显著升高（P<0.05）。MSA伴认知功能障碍患者双侧额叶的NAA/Cr与病程呈负相关，与蒙特利尔认知评估量表（MoCA）评分呈正相关。