β-内酰胺类抗生素与氨基糖苷类抗生素联合作用对D群链球菌耐药菌株的影响

The effects of combined action of beta-lactame and aminoglycoside antibiotics on resistant strains of streptococcus group D.

作者信息

Zaremba L, Linda H, Dzierzanowska D

出版信息

Arch Immunol Ther Exp (Warsz). 1979;27(6):853-9.

Abstract

The aim of the paper was to study the effect of benzylpenicillin, cloxacillin and ampicillin in combination with streptomycin, kanamycin and gentamicin on antibiotic-resistant strains of Streptococcus group D. Most frequently the synergistic effect was observed when cloxacillin was combined with streptomycin (76%), cloxacillin with kanamycin (63%) and benzylpenicillin with streptomycin (53%). In some cases the synergistic effect was so pronounced that MIC of two antibiotics used in combination was equal or lower than levels of these antibiotics in patients sera. It is assumed that these combinations may have therapeutic meaning.

摘要

本文旨在研究苄青霉素、氯唑西林和氨苄西林分别与链霉素、卡那霉素和庆大霉素联合使用对D组链球菌耐药菌株的影响。最常观察到协同作用的情况是氯唑西林与链霉素联合使用（76%）、氯唑西林与卡那霉素联合使用（63%）以及苄青霉素与链霉素联合使用（53%）。在某些情况下，协同作用非常显著，以至于联合使用的两种抗生素的最低抑菌浓度等于或低于患者血清中这些抗生素的水平。据推测，这些联合用药可能具有治疗意义。