Russell E J, Sutherland R
J Med Microbiol. 1975 Feb;8(1):1-10. doi: 10.1099/00222615-8-1-1.
Amoxycillin was more active in vitro than ampicillin or benzylpenicillin against clinical isolates of enterococci. All 55 strains tested were sensitive to the three penicillins but 15 strains showed a high level of resistance to streptomycin and two of these were also insensitive to kanamycin. All strains were sensitive to gentamicin, which was the most active of the aminoglycoside antibiotics. The penicillins showed pronounced bactericidal activity against the enterococci but failed to sterilise cultures of these organisms. Combinations of penicillins and aminoglycosides invariably produced synergistic bactericidal effects which resulted in sterilisation of cultures of these organisms. Combinations of penicillins and aminoglycosides invariably produced synergistic bactericidal effects which resulted in sterilisation of cultures of enterococci provided that the strain was sensitive to the aminoglycoside moiety of the antibiotic combination. Synergism was not observed with a combination of a penicillin and an aminoglycoside when the enterococcus was resistant to the aminoglycoside. The data reported suggest that amoxycillin may have certain advantages, compared with ampicillin or benzylpenicillin, for the treatment of enterococcal infections.
阿莫西林在体外对肠球菌临床分离株的活性比氨苄西林或苄青霉素更强。所测试的55株菌株对这三种青霉素均敏感，但有15株对链霉素表现出高度耐药性，其中两株对卡那霉素也不敏感。所有菌株对庆大霉素均敏感，庆大霉素是氨基糖苷类抗生素中活性最强的。青霉素对肠球菌显示出明显的杀菌活性，但未能使这些微生物的培养物除菌。青霉素与氨基糖苷类药物联合使用总是产生协同杀菌作用，从而使这些微生物的培养物除菌。只要菌株对抗生素组合中的氨基糖苷类部分敏感，青霉素与氨基糖苷类药物联合使用总是产生协同杀菌作用，从而使肠球菌培养物除菌。当肠球菌对氨基糖苷类耐药时，则未观察到青霉素与氨基糖苷类药物联合使用有协同作用。所报道的数据表明，与氨苄西林或苄青霉素相比，阿莫西林在治疗肠球菌感染方面可能具有某些优势。
