血浆D-二聚体水平升高与卵巢子宫内膜异位囊肿破裂有关。

Elevation of plasma D-dimer levels associated with rupture of ovarian endometriotic cysts.

作者信息

Tanaka Kei, Kobayashi Yoichi, Dozono Kei, Shibuya Hiromi, Nishigaya Yoshiko, Momomura Mai, Matsumoto Hironori, Iwashita Mitsutoshi

机构信息

Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo, Japan.

出版信息

Taiwan J Obstet Gynecol. 2015 Jun;54(3):294-6. doi: 10.1016/j.tjog.2014.09.010.

DOI:10.1016/j.tjog.2014.09.010

PMID:26166344

Abstract

OBJECTIVE

The marker for the early diagnosis of endometriotic cyst rupture is unknown. We report a preliminary study designed to evaluate the relationship between plasma D-dimer levels and endometriotic cyst rupture in clinical case series.

MATERIALS AND METHODS

We reviewed the patients' records of endometriotic cyst rupture cases, and the background (i.e., age, body mass index, and parity) and preoperative laboratory assessments (i.e., white blood cell count, levels of serum C-reactive protein, serum CA125, and plasma D-dimer) of the patients were compared with those of unruptured cases.

RESULTS

Emergency surgery cases of endometriotic cyst rupture (n = 6) and planned surgery cases of unruptured endometriotic cysts as controls (n = 16) were reviewed. Backgrounds of the patients were not significantly different between the two groups. The plasma D-dimer level was significantly higher in the rupture cases (8.5 μg/mL vs. 0.20 μg/mL, p < 0.001). Differences in white blood cell count and serum C-reactive protein level, but not serum CA125 level, were found to be statistically significant between groups.

CONCLUSION

An elevation of plasma D-dimer level is associated with endometriotic cyst rupture.

摘要

目的

子宫内膜异位囊肿破裂的早期诊断标志物尚不清楚。我们报告一项初步研究，旨在评估临床病例系列中血浆D-二聚体水平与子宫内膜异位囊肿破裂之间的关系。

材料与方法

我们回顾了子宫内膜异位囊肿破裂病例的患者记录，并将患者的背景（即年龄、体重指数和产次）以及术前实验室评估（即白细胞计数、血清C反应蛋白水平、血清CA125和血浆D-二聚体）与未破裂病例进行比较。

结果

回顾了子宫内膜异位囊肿破裂的急诊手术病例（n = 6）和未破裂子宫内膜异位囊肿的择期手术病例作为对照（n = 16）。两组患者的背景无显著差异。破裂病例的血浆D-二聚体水平显著更高（8.5μg/mL对0.20μg/mL，p < 0.001）。发现两组之间白细胞计数和血清C反应蛋白水平存在差异，但血清CA125水平无差异，且差异具有统计学意义。