一名卵巢癌患者的副肿瘤性小脑变性
Paraneoplastic cerebellar degeneration in a patient with ovarian cancer.
作者信息
Chien Hung-Ju, Lee Chuo-Yu, Chen Lu-An, Wu Chao-Chih, Chang Chih-Long
机构信息
Department of Obstetrics and Gynecology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
Department of Neurology, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan.
出版信息
Taiwan J Obstet Gynecol. 2015 Jun;54(3):313-5. doi: 10.1016/j.tjog.2014.03.012.
OBJECTIVE
Herein, we report a case of ovarian serous carcinoma with paraneoplastic cerebellar degeneration.
CASE REPORT
A 44-year-old female presented to our hospital with dizziness, slurred speech, and ataxic gait. Brain magnetic resonance imaging was normal. A lumbar puncture revealed a normal cell count in the cerebrospinal fluid, but slightly elevated protein. Her serum cancer antigen -125 level was high (2126.4 U/mL), and abdominal computed tomography disclosed a pelvic mass measuring 11 cm in diameter. Exploratory laparotomy was then performed, and a frozen section of the tumor revealed serous carcinoma.
CONCLUSION
According to the surgical findings and pathological report, The International Federation of Gynecology and Obstetrics (FIGO) Stage IIIC, Grade 3, serous-type ovarian cancer was diagnosed. Due to the abovementioned symptoms and signs, we performed a serial test to document the presence of anti-Yo antibody in this patient.
目的
在此，我们报告一例伴有副肿瘤性小脑变性的卵巢浆液性癌病例。
病例报告
一名44岁女性因头晕、言语不清和共济失调步态前来我院就诊。脑部磁共振成像正常。腰椎穿刺显示脑脊液细胞计数正常，但蛋白略有升高。她的血清癌抗原-125水平很高（2126.4 U/mL），腹部计算机断层扫描显示盆腔有一个直径11厘米的肿块。随后进行了剖腹探查术，肿瘤的冰冻切片显示为浆液性癌。
结论
根据手术结果和病理报告，诊断为国际妇产科联盟（FIGO）IIIC期、3级、浆液性卵巢癌。由于上述症状和体征，我们对该患者进行了一系列检查以证实抗Yo抗体的存在。
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