Kozhemiakin L A, Shelepina E P, Antonov V G, Kraevoĭ S A
Radiobiologiia. 1989 Nov-Dec;29(6):749-53.
Xanthine oxidase activity in thymocytes was studied at different time intervals after X-irradiation with doses of 0.5, 2 and 8 Gy. It was shown that 3 h and later after irradiation, dehydrogenase activity of the enzyme was converted into oxidase one. In the case of arresting the proteolysis by the effect of low doses (up to 0.5 Gy) and at early times the possibility of conversion of the enzyme into the dehydrogenase form was retained. The hyperactivity of the oxidase form of xanthine oxidase was probably a factor of expressing the proteolysis response and cell lysis.
研究了在0.5、2和8 Gy剂量的X射线照射后不同时间间隔胸腺细胞中的黄嘌呤氧化酶活性。结果表明，照射后3小时及更晚，该酶的脱氢酶活性转化为氧化酶活性。在低剂量（高达0.5 Gy）作用下以及早期抑制蛋白水解的情况下，酶转化为脱氢酶形式的可能性得以保留。黄嘌呤氧化酶氧化酶形式的高活性可能是表达蛋白水解反应和细胞裂解的一个因素。
