伊朗北部戈勒斯坦省饮用水中的氟化物与其母乳中氟化物水平的相关性。
Correlation between Fluoride in Drinking Water and Its Levels in Breast Milk in Golestan Province, Northern Iran.
作者信息
Faraji Hossein, Mohammadi Ali Akbar, Akbari-Adergani Behrouz, Vakili Saatloo Naimeh, Lashkarboloki Gholamreza, Mahvi Amir Hossein
机构信息
School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Dept. of Environmental Health Engineering, Neyshabur University of Medical Sciences, Neyshabur, Iran.
出版信息
Iran J Public Health. 2014 Dec;43(12):1664-8.
BACKGROUND
Fluoride is an essential element for human health. However, excess fluoride in drinking water may cause dental and/or skeletal fluorosis. Drinking water is the main route of fluoride intake. The aim of the present study was to measure fluoride levels in human breast milk collected from two regions of Golestan Province, northern Iran with different amount of fluoride concentration of drinking water in Bandar Gaz and Nokande cities and to correlate it with fluoride concentrations in drinking water used by mothers living in these two areas.
METHODS
Twenty samples of water were collected from seven drinking water wells during 2012 from Bandar Gaz and Nokande in Iran during 2012. Fluoride concentration of water samples was measured using SPADNS method. Sixty breast milk samples were collected from lactating mothers of Bandar Gaz and Nokande cities. Content in breast milk was determined using standard F ion-selective electrode. Spearman's rho correlation analysis was used to assess any possible relationship between fluoride levels in breast milk and in drinking water.
RESULTS
The means and standard deviation for F concentration in breast milk and drinking water were 0.002188±0.00026224 ppm and 0.5850±0.22542 ppm, respectively. Analysis of data showed that the variables were not normally distributed so the Spearman correlation coefficient between two variables calculated (ρ S = 0.65) and it was significant (P=0.002).
CONCLUSION
Fluoride concentration in water can directly act on its concentration in breast milk. We speculate that modifying F concentration in water can affect accessibility of fluoride for infants.
背景
氟是人体健康的必需元素。然而，饮用水中氟过量可能会导致牙齿和/或骨骼氟中毒。饮用水是氟摄入的主要途径。本研究的目的是测量从伊朗北部戈勒斯坦省两个地区采集的母乳中的氟含量，这两个地区分别是 Bandar Gaz 和 Nokande 市，其饮用水中氟浓度不同，并将其与居住在这两个地区的母亲所使用的饮用水中的氟浓度进行关联。
方法
2012 年期间，从伊朗 Bandar Gaz 和 Nokande 的七口水井中采集了 20 份水样。使用 SPADNS 方法测量水样中的氟浓度。从 Bandar Gaz 和 Nokande 市的哺乳期母亲中采集了 60 份母乳样本。使用标准氟离子选择电极测定母乳中的含量。采用 Spearman 秩相关分析评估母乳和饮用水中氟含量之间的任何可能关系。
结果
母乳和饮用水中氟浓度的均值和标准差分别为 0.002188±0.00026224 ppm 和 0.5850±0.22542 ppm。数据分析表明变量不呈正态分布，因此计算出两个变量之间的 Spearman 相关系数（ρS = 0.65），且具有显著性（P = 0.002）。
结论
水中的氟浓度可直接影响母乳中的氟浓度。我们推测改变水中的氟浓度会影响婴儿对氟的摄取。
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