Koppensteiner R, Jung M, Minar E, Ehringer H
1st Department of Medicine, University of Vienna, Austria.
Thromb Res. 1989 Oct 15;56(2):277-87. doi: 10.1016/0049-3848(89)90169-2.
The course of fibrinogen (Fgen), red cell aggregation (RCA), plasma viscocity (PV), platelet aggregation (PA) and hematocrit (Hc) was studied in patients with ultrahigh - dose thrombolytic therapy (1.5 x 10(6) units/hour for 6 hours = 1 cycle) with streptokinase (SK) or urokinase (UK) over a period of 3 cycles. Both ultrahigh - dose SK and UK produced significant changes in the course of Fgen, RCA and PV, whereas PA (spontaneous and ADP-induced) and Hc remained unchanged. After termination of each cycle Fgen progressively increased while RCA and PV further decreased. The extent of alteration in cycle 1 - concerning the baseline values - was more pronounced with SK than with UK, but the overall effect of SK decreased through the consecutive cycles because of more rapid increase during the SK-free period. In UK-therapy hemorheological alterations were initially moderate but increased from cycle to cycle.
对接受链激酶（SK）或尿激酶（UK）进行超高剂量溶栓治疗（1.5×10⁶单位/小时，持续6小时 = 1个周期），共3个周期的患者，研究了纤维蛋白原（Fgen）、红细胞聚集（RCA）、血浆粘度（PV）、血小板聚集（PA）和血细胞比容（Hc）的变化过程。超高剂量的SK和UK均使Fgen、RCA和PV的变化过程发生显著改变，而PA（自发性和ADP诱导性）及Hc保持不变。每个周期结束后，Fgen逐渐升高，而RCA和PV进一步降低。与UK相比，SK在第1周期时相对于基线值的改变程度更为明显，但由于在无SK期增加更快，SK的总体效应在连续周期中降低。在UK治疗中，血液流变学改变最初较为适度，但逐周期增加。
