非心脏跳动供体心脏移植：打破禁忌
Non-Heart-Beating Donor Heart Transplantation: Breaking the Taboo.
作者信息
Fatullayev Javid, Samak Mostafa, Sabashnikov Anton, Weymann Alexander, Mohite Prashant N, García-Sáez Diana, Patil Nikhil P, Dohmen Pascal M, Popov Aron-Frederik, Simon Andre R, Zeriouh Mohamed
机构信息
Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
出版信息
Med Sci Monit Basic Res. 2015 Jul 15;21:153-6. doi: 10.12659/MSMBR.894985.
Roughly 60% of hearts offered for transplantation are rejected because of organ dysfunction. Moreover, hearts from circulatory-dead patients have long been thought to be non-amenable for transplantation, unlike other organs. However, tentative surgical attempts inspired by the knowledge obtained from preclinical research to recover those hearts have been performed, finally culminating in clinically successful transplants. In this review we sought to address the major concerns in non-heart-beating donor heart transplantation and highlight recently introduced developments to overcome them.
大约60%用于移植的心脏因器官功能障碍而被拒收。此外，长期以来人们一直认为，与其他器官不同，来自循环死亡患者的心脏不适用于移植。然而，受临床前研究所得知识启发，人们已经尝试对这些心脏进行恢复性手术，最终实现了临床上的成功移植。在这篇综述中，我们试图探讨非心脏跳动供体心脏移植中的主要问题，并强调最近为克服这些问题而取得的进展。
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