Real-time band-selective homonuclear proton decoupling for improving sensitivity and resolution in phase-sensitive J-resolved spectroscopy.

Real-time band-selective homonuclear (1) H decoupling during data acquisition of z-filtered J-resolved spectroscopy produces (1) H-decoupled (1) H NMR spectra and leads to sensitivity enhancement and improved resolution, and thus aids the measurement of J couplings and residual dipolar couplings in crowded regions of (1) H NMR spectrum. High quality spectra from peptides, organic molecules, and also from enantiomers dissolved in weakly aligned chiral media are reported.