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美国国防部高级研究计划局的大型机制项目。

DARPA's Big Mechanism program.

作者信息

Cohen Paul R

机构信息

Defense Advanced Research Projects Agency (DARPA).

出版信息

Phys Biol. 2015 Jul 16;12(4):045008. doi: 10.1088/1478-3975/12/4/045008.

Abstract

Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

摘要

还原论科学产生复杂系统小片段的因果模型。构建整个系统的因果模型可能很困难,因为关于它们的已知信息分布在大量文献中。大机制计划旨在让机器阅读文献,并自动将各篇论文中发现的因果片段组装成巨大的因果模型。该计划目前的领域是与Ras驱动的癌症相关的细胞信号传导。

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