Buday L
I. sz. Kémiai-Biokémiai Intézet, Semmelweis Orvostudományi Egyetem, Budapest.
Orv Hetil. 1994 Nov 20;135(47):2579-84.
Growth factors, such as insulin, EGF, PDGF, are indispensable elements of the regulation of cell proliferation. In the last years signal transduction pathways of many growth factors have been elucidated. p21 ras, a proto-oncogene product, plays a central role in growth signalling. The medical importance of the investigation of Ras proteins comes from the fact that mutant forms of Ras genes were found in a number of human tumours. The review summarizes the signal transduction pathways of growth factors, with special respect to the connection of protooncogenes, tumour suppressor genes and cancer research.
生长因子，如胰岛素、表皮生长因子（EGF）、血小板衍生生长因子（PDGF），是细胞增殖调节中不可或缺的要素。在过去几年里，许多生长因子的信号转导途径已被阐明。原癌基因产物p21 ras在生长信号传导中起核心作用。对Ras蛋白进行研究具有医学重要性，原因在于在许多人类肿瘤中发现了Ras基因的突变形式。这篇综述总结了生长因子的信号转导途径，特别关注原癌基因、肿瘤抑制基因与癌症研究之间的联系。
